Morioka Masayo, Kumatoriya Tomoyuki, Morooka Takeshi, Watanabe Keisuke, Tayama Junko, Shimomura Toshiyuki, Furuya Hitoshi
Nara Emergency and Critical Care Medical Center, Nara Prefectural Nara Hospital, Nara 631 0846.
Masui. 2006 Jan;55(1):55-8.
Propofol and droperidol decrease the incidence of postoperative nausea and vomiting (PONV). We investigated the incidence of PONV after total intravenous anesthesia (TIVA) with propofol alone versus combined use of droperidol and propofol.
Eighty three patients, who had undergone laparoscopic gynecologic surgery with TIVA using propofol and fentanyl, were retrospectively evaluated whether droperidol had affected the incidence of early (up to six hours postoperatively) and late (6-24 hours postoperatively) PONV. Group D (46 patients) received droperidol intravenously at the end of surgery. Group N (37 patients) received no droperidol.
The incidences of early nausea were 27% in Group N and 4% in Group D (P<0.01). The incidences of early vomiting were 0% in Group N and 8% in Group D. The incidences of late nausea were 14% in Group N and 13% in Group D. The incidences of late vomiting were 3% in Group N and 7% in Group D.
Droperidol was useful in reducing the incidence of early nausea and vomiting after total intravenous anesthesia with propofol and fentanyl in the patients undergoing laparoscopic surgery.
丙泊酚和氟哌利多可降低术后恶心呕吐（PONV）的发生率。我们研究了单纯使用丙泊酚进行全静脉麻醉（TIVA）与联合使用氟哌利多和丙泊酚后PONV的发生率。
回顾性评估83例接受丙泊酚和芬太尼TIVA的腹腔镜妇科手术患者，氟哌利多是否影响早期（术后6小时内）和晚期（术后6 - 24小时）PONV的发生率。D组（46例患者）在手术结束时静脉注射氟哌利多。N组（37例患者）未接受氟哌利多。
N组早期恶心发生率为27%，D组为4%（P<0.01）。N组早期呕吐发生率为0%，D组为8%。N组晚期恶心发生率为14%，D组为13%。N组晚期呕吐发生率为3%，D组为7%。
在接受腹腔镜手术的患者中，氟哌利多有助于降低丙泊酚和芬太尼全静脉麻醉后早期恶心呕吐的发生率。
