Yoshimi Akihide, Arai Shunya, Iijima Kimiko, Iki Seiko, Usuki Kensuke, Urabe Akio
Division of Hematology, NTT Kanto Medical Center.
Rinsho Ketsueki. 2005 Oct;46(10):1109-13.
CD20 is usually expressed on tumor cells in Waldenström's macroglobulinemia (WM). We report on two patients who achieved good responses with rituximab treatment. <Case 1> A 78-year-old man had anemia and was referred to our hospital in 1997. On admission, IgM-kappa monoclonal protein was detected in the serum and the IgM level was 4850 mg/dl, leading to the diagnosis of WM. In 2002, he developed heart failure due to anemia, and was treated with rituximab. The IgM level decreased to about 200 mg/dl and remained unelevated for 2.5 years. The anemia also improved. < Case 2 > A 59-year-old man was found to have elevated serum IgM (4850 mg/dl) and came to our hospital in 1998. IgM-kappa monoclonal protein was detected in the serum and he was diagnosed as having WM. His IgM level had been controlled with cyclophosphamide administration, but elevated levels were noted again in 2004. He was given rituximab, and a partial response was obtained (IgM 995 mg/dl).
CD20通常在华氏巨球蛋白血症（WM）的肿瘤细胞上表达。我们报告了两名使用利妥昔单抗治疗取得良好疗效的患者。<病例1>一名78岁男性患有贫血，于1997年转诊至我院。入院时，血清中检测到IgM-κ单克隆蛋白，IgM水平为4850mg/dl，诊断为WM。2002年，他因贫血发展为心力衰竭，并接受了利妥昔单抗治疗。IgM水平降至约200mg/dl，并在2.5年内未再升高。贫血也有所改善。<病例2>一名59岁男性于1998年被发现血清IgM升高（4850mg/dl），并前来我院就诊。血清中检测到IgM-κ单克隆蛋白，他被诊断为WM。他的IgM水平曾通过环磷酰胺给药得到控制，但在2004年再次出现升高。他接受了利妥昔单抗治疗，并获得了部分缓解（IgM 995mg/dl）。
