Takasaki Hirotaka, Takabayashi Maki, Yamaji Satoshi, Koharazawa Hideyuki, Fujimaki Katsumichi, Kanamori Heiwa, Ishigatsubo Yoshiaki
Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine.
Rinsho Ketsueki. 2005 Feb;46(2):144-6.
An 84-year-old man was diagnosed as having pulmonary MALT lymphoma in January 1997. Six years later, he was admitted to our hospital with coughing and dyspnea in November 2003. Dissemination of MALT lymphoma was confirmed by findings of pleural effusion and bone marrow aspiration. A FISH analysis of cells from the pleural effusion revealed t(11;18)(q21;q21) and the serum level of IgM was 8,600 mg/dl (M-protein). The diagnosis of secondary macroglobulinemia was made. The patient received rituximab monotherapy because he was very elderly. Pleural effusion has not been seen after the administration of rituximab, although there have been no changes in the lung mass and serum values of M-protein.
一名84岁男性于1997年1月被诊断为肺黏膜相关淋巴组织淋巴瘤。六年后，即2003年11月，他因咳嗽和呼吸困难入住我院。胸腔积液和骨髓穿刺结果证实了黏膜相关淋巴组织淋巴瘤的播散。对胸腔积液细胞进行的荧光原位杂交分析显示t(11;18)(q21;q21)，血清IgM水平为8600mg/dl（M蛋白）。诊断为继发性巨球蛋白血症。由于患者年事已高，接受了利妥昔单抗单药治疗。使用利妥昔单抗后未再出现胸腔积液，尽管肺部肿块和M蛋白血清值没有变化。
