含膦新型水溶性环戊二烯基钌（II）配合物的合成、表征及与DNA的结合
Synthesis, characterization, and DNA binding of new water-soluble cyclopentadienyl ruthenium(II) complexes incorporating phosphines.
作者信息
Romerosa Antonio, Campos-Malpartida Tatiana, Lidrissi Chaker, Saoud Mustapha, Serrano-Ruiz Manuel, Peruzzini Maurizio, Garrido-Cárdenas Jose Antonio, García-Maroto Federico
机构信息
Area de Química Inorgánica, Facultad de Ciencias, Universidad de Almería, Almería, Spain.
出版信息
Inorg Chem. 2006 Feb 6;45(3):1289-98. doi: 10.1021/ic051053q.
The new water-soluble ruthenium(II) chiral complexes RuCpX(L)(L') (X = Cl, I. L = PPh3; L' = PTA, mPTA; L = L' = PTA, mPTA) (PTA = 1,3,5-triaza-7-phosphaadamantane; mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane) have been synthesized and characterized by NMR and IR spectroscopy and elemental analysis. The salt mPTA(OSO2CF3) was also prepared and fully characterized by spectroscopic techniques. X-ray crystal structures of [RuClCp(PPh3)(PTA)] (2), [RuCpI(PPh3)(PTA)] (3), and RuCpI(mPTA)(PPh3) (9) have been determined. The binding properties toward DNA of the new hydrosoluble complexes have been studied using the mobility shift assay. The ruthenium chloride complexes interact with DNA depending on the hydrosoluble phosphine bonded to the metal, while the corresponding compounds with iodide, [RuCpI(PTA)2] (1), [RuCpI(PPh3)(PTA)] (3), RuCpI(mPTA)22 (6), and RuCpI(mPTA)(PPh3) (9), do not bind to DNA.
新型水溶性钌（II）手性配合物RuCpX（L）（L'）（X = Cl、I；L = PPh3；L' = PTA、mPTA；L = L' = PTA、mPTA）（PTA = 1,3,5 - 三氮杂 - 7 - 磷杂金刚烷；mPTA = N - 甲基 - 1,3,5 - 三氮杂 - 7 - 磷杂金刚烷）已通过核磁共振、红外光谱和元素分析进行了合成与表征。盐mPTA(OSO2CF3)也已制备，并通过光谱技术进行了全面表征。已测定了[RuClCp(PPh3)(PTA)]（2）、[RuCpI(PPh3)(PTA)]（3）和RuCpI(mPTA)(PPh3)（9）的X射线晶体结构。使用迁移率变动分析研究了新型水溶性配合物与DNA的结合特性。氯化钌配合物与DNA的相互作用取决于与金属键合的水溶性膦，而相应的碘化物化合物[RuCpI(PTA)2]（1）、[RuCpI(PPh3)(PTA)]（3）、RuCpI(mPTA)22（6）和RuCpI(mPTA)(PPh3)（9）不与DNA结合。
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