Loucks Eric B, Sullivan Lisa M, D'Agostino Ralph B, Larson Martin G, Berkman Lisa F, Benjamin Emelia J
Department of Society, Human Development & Health, Harvard School of Public Health, Boston, MA, USA.
J Biosoc Sci. 2006 Nov;38(6):835-42. doi: 10.1017/S0021932005001203. Epub 2006 Jan 27.
Lack of social integration predicts coronary heart disease mortality in prospective studies; however, the biological pathways that may be responsible are poorly understood. The specific aims of this study were to examine whether social networks are associated with serum concentrations of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1). Participants in the Framingham Study attending examinations from 1998 to 2001 (n=3267) were eligible for inclusion in the study. Social networks were assessed using the Berkman-Syme Social Network Index (SNI). Concentrations of IL-6, CRP, sICAM-1 and MCP-1 were measured in fasting serum samples. Multivariable linear regression analyses were used to assess the association of social networks with inflammatory markers adjusting for potential confounders including age, smoking, blood pressure, total:HDL cholesterol ratio, body mass index, lipid-lowering and antihypertensive medication, diabetes, cardiovascular disease, depression and socioeconomic status. Results found that the SNI was significantly inversely associated with IL-6 in men (p=0.03) after adjusting for potential confounders. In age-adjusted analyses, social networks also were significantly inversely associated with IL-6 for women (p=0.03) and were marginally to modestly associated with CRP and sICAM-1 for men (p=0.08 and 0.02, respectively), but these associations were not significant in the multivariate analyses. In conclusion, social networks were found to be inversely associated with interleukin-6 levels in men. The possibility that inflammatory markers may be potential mediators between social integration and coronary heart disease merits further investigation.
在前瞻性研究中，社会融合的缺乏预示着冠心病死亡率；然而，可能与之相关的生物学途径却知之甚少。本研究的具体目的是检验社交网络是否与炎症标志物白细胞介素-6（IL-6）、C反应蛋白（CRP）、可溶性细胞间黏附分子-1（sICAM-1）和单核细胞趋化蛋白-1（MCP-1）的血清浓度相关。参加1998年至2001年弗雷明汉姆研究检查的参与者（n = 3267）符合纳入本研究的条件。使用伯克曼-赛姆社交网络指数（SNI）评估社交网络。在空腹血清样本中测量IL-6、CRP、sICAM-1和MCP-1的浓度。采用多变量线性回归分析来评估社交网络与炎症标志物之间的关联，并对潜在混杂因素进行校正，这些混杂因素包括年龄、吸烟、血压、总胆固醇与高密度脂蛋白胆固醇比值、体重指数、降脂和抗高血压药物、糖尿病、心血管疾病、抑郁症和社会经济地位。结果发现，在对潜在混杂因素进行校正后，男性的SNI与IL-6显著负相关（p = 0.03）。在年龄校正分析中，社交网络与女性的IL-6也显著负相关（p = 0.03），与男性的CRP和sICAM-1有轻微至中度关联（分别为p = 0.08和0.02），但这些关联在多变量分析中并不显著。总之，发现社交网络与男性白细胞介素-6水平呈负相关。炎症标志物可能是社会融合与冠心病之间潜在中介因素的可能性值得进一步研究。
