Kim Karen H, Geronemus Roy G
Laser and Skin surgery Center of New York, NY, USA.
Dermatol Surg. 2006 Feb;32(2):241-48; discussion 247.
We studied the safety and efficacy of a 1,064 nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser with a 300-micron fiber for the reduction of small unwanted fat areas.
Thirty subjects with focal areas of fat less than 100 cc were enrolled. Ten subjects were treated with laser lipolysis and had magnetic resonance imaging (MRI) at baseline and 3 months post-treatment. Ten subjects had laser lipolysis followed by biweekly treatments with the Tri-active system. The last group of 10 subjects served as control. Patients were seen at baseline and 1-week, 1-month, and 3-month follow-up visits.
Twenty-nine patients completed the study. Self-assessment evaluations reported an improvement of 37% at the 3-month follow-up visit. MRI demonstrated an average 17% reduction in fat volume. Smaller baseline volume areas, such as the submentum, had better results, suggesting a dose-response relationship. The most common side effects were mild bruising and swelling resolving within 2 weeks.
Laser lipolysis using the 1,064 nm Nd:YAG laser with a 300-micron fiber appears to be a very promising procedure that delivers good, reproducible results safely and effectively. The advantages include excellent patient tolerance, quick recovery time, and the benefit of dermal tightening.
我们研究了使用配备300微米光纤的1064纳米钕钇铝石榴石（Nd:YAG）激光减少小面积多余脂肪的安全性和有效性。
招募了30名局部脂肪面积小于100立方厘米的受试者。10名受试者接受激光溶脂治疗，并在基线和治疗后3个月进行磁共振成像（MRI）检查。10名受试者接受激光溶脂治疗，随后每两周使用Tri-active系统进行治疗。最后一组10名受试者作为对照。在基线以及随访1周、1个月和3个月时对患者进行检查。
29名患者完成了研究。自我评估报告显示，在3个月的随访中改善率为37%。MRI显示脂肪体积平均减少了17%。较小的基线体积区域，如下颌下区，效果更好，提示存在剂量反应关系。最常见的副作用是轻度瘀伤和肿胀，在2周内消退。
使用配备300微米光纤的1064纳米Nd:YAG激光进行激光溶脂似乎是一种非常有前景的方法，能够安全有效地产生良好且可重复的效果。其优点包括患者耐受性良好、恢复时间短以及具有皮肤紧致的益处。
