Duschek Stefan, Schandry Rainer
Ludwig-Maximilians-Universität München, Department Psychologie, Leopoldstr. 13, 80802 Munich, Germany.
Biol Psychol. 2006 Jun;72(3):311-7. doi: 10.1016/j.biopsycho.2005.12.003. Epub 2006 Jan 25.
The present study aimed to investigate aberrances in the adjustment of cerebral blood flow to cognitive activity due to chronically low blood pressure. By means of transcranial Doppler sonography blood flow velocities in both middle cerebral arteries (MCA) were recorded during the execution of a serial subtraction task in 40 subjects with constitutional hypotension and 40 normotensive control persons. Additionally, blood pressure was continuously monitored. As a main result significant correlations between the task-induced changes in blood pressure and those in MCA blood flow velocities were found in hypotensives, but not in control subjects. The dependence of the regulation of cerebral blood flow on blood pressure points towards deficits in cerebral autoregulation in hypotension. Over the total sample the extent of the task-induced MCA flow velocity increase was positively related to cognitive performance. This underlines the importance of the adjustment of cerebral blood flow to current demands for optimal cognitive functioning.
本研究旨在调查由于长期低血压导致的脑血流对认知活动调节的异常情况。通过经颅多普勒超声检查，在40名体质性低血压患者和40名血压正常的对照者执行连续减法任务期间，记录了双侧大脑中动脉（MCA）的血流速度。此外，还持续监测了血压。主要结果是，在低血压患者中发现任务诱导的血压变化与MCA血流速度变化之间存在显著相关性，而在对照受试者中未发现。脑血流调节对血压的依赖性表明低血压患者脑自动调节存在缺陷。在整个样本中，任务诱导的MCA血流速度增加程度与认知表现呈正相关。这强调了将脑血流调节至当前需求以实现最佳认知功能的重要性。
