Pinaya Walter H L, Fraga Francisco J, Haratz Salo S, Dean Philip J A, Conforto Adriana B, Bor-Seng-Shu Edson, Teixeira Manoel J, Sato João R
Center for Engineering, Modeling and Applied Social Sciences, Universidade Federal do ABC, Rua Santa Adélia, 166 - Bairro Bangu, Santo André, SP, CEP 09.210-170, Brazil,
J Med Syst. 2015 Feb;39(2):4. doi: 10.1007/s10916-014-0185-z. Epub 2015 Jan 27.
The lateralization index (LI) as determined from functional transcranial Doppler sonography (fTCD) can be used to determine the hemispheric organization of neural activation during a behavioral task. Previous studies have proposed different methods to determine this index, but to our knowledge no studies have compared the performance of these methods. In this study, we compare two established methods with a simpler method proposed here. The aim was to see whether similar results could be achieved with a simpler method and to give an indication of the analysis steps required to determine the LI. A simple unimanual motor task was performed while fTCD was acquired, and the LI determined by each of these methods was compared. In addition, LI determined by each method was related to behavioural output in the form of degree of handedness. The results suggest that although the methods differed in complexity, they yielded similar results when determining the lateralization of motor functions, and its correlation with behavior. Further investigation is needed to expand the conclusions of this preliminary study, however the new method proposed in the paper has great potential as it is much simpler than the more established methods yet yields similar results.
通过功能性经颅多普勒超声（fTCD）测定的偏侧化指数（LI）可用于确定行为任务期间神经激活的半球组织。先前的研究提出了不同的方法来确定该指数，但据我们所知，尚无研究比较这些方法的性能。在本研究中，我们将两种既定方法与本文提出的一种更简单的方法进行比较。目的是看看使用更简单的方法是否能获得相似的结果，并指出确定LI所需的分析步骤。在采集fTCD的同时进行了一项简单的单手运动任务，并比较了通过每种方法确定的LI。此外，通过每种方法确定的LI与以利手程度形式表现的行为输出相关。结果表明，尽管这些方法在复杂性上有所不同，但在确定运动功能的偏侧化及其与行为的相关性时，它们产生了相似的结果。然而，需要进一步研究来扩展这项初步研究的结论，不过本文提出的新方法具有很大的潜力，因为它比更成熟的方法简单得多，但却能产生相似的结果。
