Mehta Jawahar L, Rasouli Neda, Sinha Anjan K, Molavi Behzad
Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Health Care System, Little Rock, 72205-7199, USA.
Int J Biochem Cell Biol. 2006;38(5-6):794-803. doi: 10.1016/j.biocel.2005.12.008. Epub 2006 Jan 18.
Diabetes is a major risk factor for atherosclerosis. Atherogenesis involves endothelial dysfunction, activation and injury, inflammation, and smooth muscle cell migration and proliferation. Platelet activation in the narrowed arteries is the most proximate event in the culmination of an acute event such as acute myocardial infraction and stroke. Hyperglycemia is associated with all these adverse events in the process of genesis of atherosclerosis. The effect of diabetes (hyperglycemia) is mediated in large part by the state of enhanced oxidative stress, which is not counter-balanced by endogenous antioxidants. This paper reviews the ignition of oxidative stress in diabetes and the mediation of events leading to atherogenesis.
糖尿病是动脉粥样硬化的主要危险因素。动脉粥样硬化的发生涉及内皮功能障碍、激活与损伤、炎症以及平滑肌细胞迁移和增殖。在诸如急性心肌梗死和中风等急性事件的发生过程中，狭窄动脉中的血小板激活是最直接的事件。高血糖与动脉粥样硬化发生过程中的所有这些不良事件相关。糖尿病（高血糖）的影响在很大程度上是由氧化应激增强状态介导的，而内源性抗氧化剂无法对其进行平衡。本文综述了糖尿病中氧化应激的引发以及导致动脉粥样硬化事件的介导过程。
