Wada R, Yagihashi S, Konta R, Ueda T, Izumiyama T
Department of Pathology, Hirosaki University School of Medicine, Japan.
Gut. 1992 Jul;33(7):994-6. doi: 10.1136/gut.33.7.994.
A rare case of gastric polyposis caused by infiltration of Langerhans' cells is reported. A 53 year old Japanese woman complaining of vague abdominal discomfort, was found at endoscopy to have numerous polyps all over the gastric wall. An endoscopic biopsy specimen showed characteristic infiltration of Langerhans' cells in the lamina propria of the mucosa. Functional abnormalities such as impaired gastric acid secretion or malabsorption were not associated with this lesion and the patient was treated conservatively. During follow up over two years, she had a cutaneous eruption with infiltration of histiocytes and osteolytic lesions in the skull. However, no progressive changes occurred in the stomach. This probably benign self-limiting lesion of gastric histiocytosis X may be one of the manifestations of multifocal histiocytosis X, but its aetiology and appropriate treatment have not yet been determined.
报告了一例罕见的由朗格汉斯细胞浸润引起的胃息肉病。一名53岁的日本女性，主诉腹部隐痛，内镜检查发现胃壁布满大量息肉。内镜活检标本显示黏膜固有层有特征性的朗格汉斯细胞浸润。该病变未伴有胃酸分泌受损或吸收不良等功能异常，患者接受了保守治疗。在两年多的随访期间，她出现了皮肤组织细胞浸润性皮疹和颅骨溶骨性病变。然而，胃部未出现进展性变化。这种可能为良性自限性的胃组织细胞增生症X病变可能是多灶性组织细胞增生症X的表现之一，但其病因及恰当治疗方法尚未明确。
