Nihei K, Terashima K, Aoyama K, Imai Y, Sato H
Acta Pathol Jpn. 1983 May;33(3):577-88. doi: 10.1111/j.1440-1827.1983.tb00364.x.
Histiocytosis X of the stomach of a 47-year-old Japanese woman, who underwent subtotal gastrectomy following a clinical diagnosis of scirrhous carcinoma, was studied by light and electron microscopy as well as by immunohistochemistry. The histiocytoid cells proliferated monotonously in the lamina propria mucosae of the atrophied mucosa covering the body and fornix. They were arranged in a sheet- or pavement stone-pattern and included some giant cells. The histiocytoid cells had a reniform to irregularly indented nucleus and conspicuous cytoplasm. Ultrastructurally, they were characterized by interdigitating cytoplasmic extensions and abundant tubulovesicular structures including Langerhans granules. S-100 protein, alpha 1-antitrypsin, and alpha 1-antichymotrypsin were immunohistochemically identified in the cytoplasm. Endoscopic biopsies of the extragastric digestive tract, a biopsy of the lymph node, and bone marrow aspiration excluded a systemic disorder. The case is regarded as benign localized histiocytosis X of the stomach, a previously undescribed gastric lesion.
对一名47岁日本女性的胃组织细胞增生症X进行了研究，该患者临床诊断为硬癌后接受了胃次全切除术，采用光镜、电镜及免疫组化方法进行观察。组织细胞样细胞在覆盖胃体和胃穹窿的萎缩黏膜固有层中呈单调增殖。它们呈片状或铺路石样排列，包含一些巨细胞。组织细胞样细胞有肾形至不规则凹陷的细胞核及明显的细胞质。超微结构上，其特征为相互交错的细胞质突起及丰富的微管泡状结构，包括朗格汉斯颗粒。免疫组化显示细胞质中有S-100蛋白、α1-抗胰蛋白酶及α1-抗糜蛋白酶。胃外消化道的内镜活检、淋巴结活检及骨髓穿刺排除了系统性疾病。该病例被认为是胃的良性局限性组织细胞增生症X，一种此前未描述过的胃部病变。
