da Costa Paulo Sérgio Gonçalves, Brigatte Marcos Emilio, Greco Dirceu Bartolomeu
Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Mem Inst Oswaldo Cruz. 2005 Dec;100(8):853-9. doi: 10.1590/s0074-02762005000800006. Epub 2006 Jan 20.
Rickettsial diseases except those belonging to spotted fever group rickettsioses are poorly studied in South America particularly in Brazil where few epidemiological reports have been published. We describe a serosurvey for Rickettsia rickettsii, R. typhi, Coxiella burnetii, Bartonella henselae, B. quintana, and Ehrlichia chaffeensis in 437 healthy people from a Brazilian rural community. The serum samples were tested by indirected micro-immunoflourescence technique and a cutoff titer of 1:64 was used. The seroprevalence rates for R. rickettsii, R. typhi, C. burnetii, B. henselae, B. quintana, and E. chaffeensis were respectively 1.6% (7 samples); 1.1% (5 samples); 3.9% (17 samples); 13.7% (60 samples); 12.8% (56 samples), and 10.5% (46 samples). Frequent multiple/cross-reactivity was observed in this study. Age over 40 years old, urban profession, and rural residence were significantly associated with some but not all infections rate. Low seropositivity rates for R. rickettsii, R. typhi, and C. burnetii contrasted with higher rates of seropositivity for B. quintana, B. henselae, and E. chaffeensis. These results show that all tested rickettsial species or antigenically closely related possible exist in this particular region.
除斑点热群立克次体病外，南美洲对其他立克次体病的研究较少，尤其是在巴西，该国发表的流行病学报告很少。我们描述了对巴西一个农村社区437名健康人进行的关于立氏立克次体、伤寒立克次体、伯氏考克斯体、汉赛巴尔通体、五日热巴尔通体和查菲埃立克体的血清学调查。血清样本采用间接微量免疫荧光技术检测，截断滴度为1:64。立氏立克次体、伤寒立克次体、伯氏考克斯体、汉赛巴尔通体、五日热巴尔通体和查菲埃立克体的血清阳性率分别为1.6%（7份样本）；1.1%（5份样本）；3.9%（17份样本）；13.7%（60份样本）；12.8%（56份样本）和10.5%（46份样本）。本研究中观察到频繁的多重/交叉反应性。40岁以上的年龄、城市职业和农村居住与部分但并非所有感染率显著相关。立氏立克次体、伤寒立克次体和伯氏考克斯体的低血清阳性率与五日热巴尔通体、汉赛巴尔通体和查菲埃立克体较高的血清阳性率形成对比。这些结果表明，在这个特定区域可能存在所有检测的立克次体物种或抗原密切相关的物种。
