Shervington A, Cruickshanks N, Wright H, Atkinson-Dell R, Lea R, Roberts G, Shervington L
Department of Biological Sciences, University of Central Lancashire, Preston, UK.
Mol Cell Biochem. 2006 Feb;283(1-2):1-9. doi: 10.1007/s11010-006-2495-z.
The continuous advancements in cancer research have contributed to the overwhelming evidence of the presence of telomerase in primary and secondary tumours together with hsp90 and c-Myc. This review will discuss the important role of telomerase together with hsp90 and c-Myc within the initiation and progression of gliomas. Also it will review the differential expression of these genes in the different grades of gliomas and the possibility of new treatments targeting these specific genes.
癌症研究的持续进展为端粒酶与热休克蛋白90（hsp90）和c-Myc一起存在于原发性和继发性肿瘤中提供了大量证据。本综述将讨论端粒酶与hsp90和c-Myc在胶质瘤起始和进展过程中的重要作用。此外，还将综述这些基因在不同级别胶质瘤中的差异表达，以及针对这些特定基因的新治疗方法的可能性。
