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Can the lack of HSP90alpha protein in brain normal tissue and cell lines, rationalise it as a possible therapeutic target for gliomas?

作者信息

Shervington Amal, Cruickshanks Nichola, Lea Robert, Roberts Gareth, Dawson Tim, Shervington Leroy

机构信息

Neurosurgery Department, Royal Preston Hospital, Brain Tumor North West, Preston, UK.

出版信息

Cancer Invest. 2008 Nov;26(9):900-4. doi: 10.1080/07357900802087259.

DOI:10.1080/07357900802087259
PMID:18798074
Abstract

Despite studies suggesting a role for HSP90alpha in tumorigenesis, there are no reports as to its expression in normal human brain tissue. In this study, the expression of HSP90alpha was evaluated in both cell lines (3 gliomas and 2 controls) and brain tissue specimens of 10 patients (8 gliomas and 2 normal brain tissues). No HSP90alpha protein was detected in either normal cell lines or normal brain tissue. However, 8/8 glioma tissues and 3/3 glioma cell lines did express HSP90alpha. These findings provide a rationale for targeting HSP90alpha protein as a therapeutic candidate for glioma.

摘要

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