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Artemisone--a highly active antimalarial drug of the artemisinin class.

作者信息

Haynes Richard K, Fugmann Burkhard, Stetter Jörg, Rieckmann Karl, Heilmann Hans-Dietrich, Chan Ho-Wai, Cheung Man-Ki, Lam Wai-Lun, Wong Ho-Ning, Croft Simon L, Vivas Livia, Rattray Lauren, Stewart Lindsay, Peters Wallace, Robinson Brian L, Edstein Michael D, Kotecka Barbara, Kyle Dennis E, Beckermann Bernhard, Gerisch Michael, Radtke Martin, Schmuck Gabriele, Steinke Wolfram, Wollborn Ute, Schmeer Karl, Römer Axel

机构信息

Department of Chemistry, Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China.

出版信息

Angew Chem Int Ed Engl. 2006 Mar 20;45(13):2082-8. doi: 10.1002/anie.200503071.

DOI:10.1002/anie.200503071
PMID:16444785
Abstract
摘要

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Artemisone--a highly active antimalarial drug of the artemisinin class.青蒿甲醚——一种活性很高的青蒿素类抗疟药物。
Angew Chem Int Ed Engl. 2006 Mar 20;45(13):2082-8. doi: 10.1002/anie.200503071.
2
Progress in the research of artemisinin and its analogues as antimalarials: an update.青蒿素及其类似物作为抗疟药物的研究进展：最新情况
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3
Artemisinin resistance: how can we find it?青蒿素耐药性：我们如何发现它？
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Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.抗疟药物青蒿素的构效关系。8. 基于青蒿素开发抗利什曼病和疟疾药物的设计、合成及比较分子力场分析研究
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In vitro activity of artemisone compared with artesunate against Plasmodium falciparum.青蒿酮与青蒿琥酯对恶性疟原虫的体外活性比较。
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6
Artemisinin, a novel antimalarial drug: biochemical and molecular approaches for enhanced production.青蒿素，一种新型抗疟药物：提高产量的生化与分子方法
Planta Med. 2003 Apr;69(4):289-99. doi: 10.1055/s-2003-38871.
7
Fluoroartemisinin: trifluoromethyl analogues of artemether and artesunate.氟代青蒿素：蒿甲醚和青蒿琥酯的三氟甲基类似物。
J Med Chem. 2004 May 6;47(10):2694-9. doi: 10.1021/jm0310333.
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Quinolines and artemisinin: chemistry, biology and history.喹啉与青蒿素：化学、生物学及历史
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Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.青蒿酮联合传统抗疟药物治疗小鼠脑型疟疾：抗疟原虫作用及免疫反应
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Adv Pharmacol. 1997;37:253-97. doi: 10.1016/s1054-3589(08)60952-7.

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