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天然产物与药物发现

Natural products and drug discovery.

作者信息

Newman David J

机构信息

NIH Special Volunteer, Wayne, PA 19087, USA.

出版信息

Natl Sci Rev. 2022 Sep 29;9(11):nwac206. doi: 10.1093/nsr/nwac206. eCollection 2022 Nov.

DOI:10.1093/nsr/nwac206
PMID:36404871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9668068/
Abstract

This review covers the recent history of a series of very important natural products and their derivatives that are currently in use or under evaluation in the areas of anti-infectives, important cancer treatments that include antibody drug conjugates, followed by a discussion of type 2 diabetes (T2DM) drugs and angiotensin converting enzyme inhibitors. The current structures of the agents are shown, though in the case of some peptides used in T2DM drugs the standard single letter abbreviation for an amino acid is used.

摘要

本综述涵盖了一系列非常重要的天然产物及其衍生物的近期历史，这些天然产物及其衍生物目前正在抗感染领域、包括抗体药物偶联物在内的重要癌症治疗领域中使用或处于评估阶段，随后讨论了2型糖尿病（T2DM）药物和血管紧张素转换酶抑制剂。文中展示了这些药物的当前结构，不过对于T2DM药物中使用的一些肽，采用了氨基酸的标准单字母缩写。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/1d7452f793b0/nwac206fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/8a47879d371c/nwac206fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/93198a935a50/nwac206fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/f9ddca570ba1/nwac206fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/08d345ef9f60/nwac206fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/abcaa04170d4/nwac206fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/7da01070a491/nwac206fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/a284440adfe5/nwac206fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/129b25fc5732/nwac206fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/5c300088d822/nwac206fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/53a53e029dff/nwac206figsc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/7ff6750bd5e9/nwac206fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/7115c0a6c780/nwac206fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/cba175df1f43/nwac206fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/1d7452f793b0/nwac206fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/8a47879d371c/nwac206fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/93198a935a50/nwac206fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/f9ddca570ba1/nwac206fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/08d345ef9f60/nwac206fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/abcaa04170d4/nwac206fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/7da01070a491/nwac206fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/a284440adfe5/nwac206fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/129b25fc5732/nwac206fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/5c300088d822/nwac206fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/53a53e029dff/nwac206figsc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/7ff6750bd5e9/nwac206fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/7115c0a6c780/nwac206fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/cba175df1f43/nwac206fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29aa/9668068/1d7452f793b0/nwac206fig13.jpg

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