Jerkeman M, Braconier J H
Dept. of Infectious Diseases, University Hospital, Lund, Sweden.
Infection. 1992 May-Jun;20(3):143-5. doi: 10.1007/BF01704603.
Patients with febrile urinary tract infections with (80 patients) or without (88 patients) positive blood cultures were reviewed. Eighty-nine percent of the infections were community acquired. The bacteremic patients were older, Escherichia coli was the most commonly found organism in both groups. The most important finding in this study was increased frequency of resistance to three common urinary tract antibiotics (ampicillin, cephalothin and trimethoprim-sulfamethoxazole) in E. coli from patients with non-bacteremic compared with bacteremic infections. Complications occurred in 28 bacteremic and in three non-bacteremic patients. Six patients died, all with bacteremia. The significantly higher temperature at admittance among patients with gram-negative versus gram-positive bacteremic infection possibly reflects an effect by endotoxin.
对有（80例患者）或无（88例患者）血培养阳性的发热性尿路感染患者进行了回顾。89%的感染为社区获得性。菌血症患者年龄较大，两组中最常见的病原体均为大肠杆菌。本研究中最重要的发现是，与菌血症感染患者相比，非菌血症患者的大肠杆菌对三种常见尿路抗生素（氨苄西林、头孢噻吩和甲氧苄啶-磺胺甲恶唑）的耐药频率增加。28例菌血症患者和3例非菌血症患者出现并发症。6例患者死亡，均为菌血症患者。革兰氏阴性菌血症感染患者入院时体温显著高于革兰氏阳性菌血症感染患者，这可能反映了内毒素的作用。
