EndoCyte，一种用于受体介导的内吞作用定量分析的交互式计算机程序。

EndoCyte, an interactive computer program for quantitative analysis of receptor-mediated endocytosis.

作者信息

Zelić A, Bajzer Z, Vuk-Pavlović S

机构信息

Division of Developmental Oncology Research, Mayo Clinic, Rochester, MN 55905.

出版信息

Int J Biomed Comput. 1992 Jul;31(1):59-70. doi: 10.1016/0020-7101(92)90054-v.

DOI:10.1016/0020-7101(92)90054-v

PMID:1644503

Abstract

We present EndoCyte, a user friendly interactive program for quantitative analysis of receptor-mediated endocytosis. The data, comprised of time-dependent concentrations of the ligand at the cell surface and the ligand internalized by cells, are analyzed by the application of a set of nested mathematical models of endocytosis. EndoCyte reduces data to parameters conventional in description of receptor-mediated endocytosis and a parameter which describes the non-linear effects. The performance of EndoCyte is documented by the analysis of applications to synthetic data.

摘要

我们展示了EndoCyte，这是一个用于受体介导的内吞作用定量分析的用户友好型交互式程序。由细胞表面配体的时间依赖性浓度和细胞内化的配体组成的数据，通过应用一组内吞作用的嵌套数学模型进行分析。EndoCyte将数据简化为受体介导的内吞作用描述中常用的参数以及一个描述非线性效应的参数。通过对合成数据应用的分析记录了EndoCyte的性能。