Vinée P, Meurer B, Constantinesco A, Kohlberger B, Hauenstein K, Petkov S
Laboratoire de Biomécanique, CHU Hautepierre, Strasbourg, France.
Invest Radiol. 1992 Jul;27(7):510-4. doi: 10.1097/00004424-199207000-00006.
Previous studies have suggested a relationship between tissue magnetic resonance (MR) relaxation times and its biomechanical behavior. To further investigate this relationship, the authors studied 41 human vascular wall samples from different anatomic localizations, including systemic and pulmonary arterial, as well as venous tissues.
The authors measured water content, proton MR T1 and T2 relaxation times, and two viscoelastic parameters of the samples at 4 MHz.
T2, water content, and both viscoelastic variables significantly differed among the five anatomic localizations (P less than .05). Both T1 and T2 were significantly (P less than .05) and linearly related to viscoelastic parameters. Multiple linear regression showed that both viscoelastic parameters of a sample can be predicted from the measured values of T1 and T2.
These results provide a basis for characterizing the mechanical stress of a tissue by knowing its MR relaxation times.
先前的研究表明组织磁共振（MR）弛豫时间与其生物力学行为之间存在关联。为进一步探究这种关系，作者研究了41个来自不同解剖部位的人体血管壁样本，包括体循环和肺动脉以及静脉组织。
作者测量了样本的含水量、质子MR T1和T2弛豫时间以及在4兆赫兹时的两个粘弹性参数。
在五个解剖部位中，T2、含水量以及两个粘弹性变量均存在显著差异（P < 0.05）。T1和T2均与粘弹性参数显著相关（P < 0.05）且呈线性关系。多元线性回归表明，样本的两个粘弹性参数均可根据T1和T2的测量值进行预测。
这些结果为通过了解组织的MR弛豫时间来表征其机械应力提供了依据。
