Constantinesco A, Gries P, Vinee P, Heckert B, Carlier P
Laboratoire de Biomecanique, CHRU de Hautepierre, Strasbourg, France.
Magn Reson Imaging. 1989 Mar-Apr;7(2):173-7. doi: 10.1016/0730-725x(89)90701-7.
We investigated the influence of the biomechanical behavior of human common carotid arterial wall on the NMR proton relaxation times using a Bruker Minispec at 4 MHz. The study was limited to low extension in simple longitudinal elongation of the carotid wall (the maximum loading stretch ratio being 40%). Twenty-five carotid samples divided into 2 longitudinal strips were tested. The first strip was used to determine the nondimensional elastic parameter alpha according to the mechanical model of Fung. The second strip was used to measure the proton relaxation times. T1 value was 316.8 ms +/- 27.6 and T2 value was 59.9 ms +/- 6.8. A significant linear correlation was found between T1 and Ln alpha (p = 0.02). T1 and T2 were not correlated to the age but linearly correlated to the tissue water content (p less than 0.0001), however the age and alpha were not correlated to the tissue water content. These results may reflect the differences in the amount of water binding sites of the elastin which is involved in the elasticity of the carotid wall at low extension.
我们使用布鲁克MiniSpec在4兆赫兹频率下研究了人类颈总动脉壁的生物力学行为对核磁共振质子弛豫时间的影响。该研究仅限于颈动脉壁简单纵向伸长时的低延伸情况（最大加载拉伸比为40%）。对25个颈动脉样本分成2个纵向条带进行了测试。第一条带用于根据冯氏力学模型确定无量纲弹性参数α。第二条带用于测量质子弛豫时间。T1值为316.8毫秒±27.6，T2值为59.9毫秒±6.8。发现T1与Lnα之间存在显著的线性相关性（p = 0.02）。T1和T2与年龄无关，但与组织含水量呈线性相关（p小于0.0001），然而年龄和α与组织含水量无关。这些结果可能反映了在低延伸情况下参与颈动脉壁弹性的弹性蛋白水结合位点数量的差异。
