锰-中卟啉和锰-四苯基卟吩四磺酸钠的肝脏对比增强特性。大鼠的一项对比磁共振成像研究。
Hepatic contrast-enhancing properties of manganese-mesoporphyrin and manganese-TPPS4. A comparative magnetic resonance imaging study in rats.
作者信息
Schmiedl U P, Nelson J A, Starr F L, Schmidt R
机构信息
Department of Radiology, University of Washington, School of Medicine, Seattle 98195.
出版信息
Invest Radiol. 1992 Jul;27(7):536-42. doi: 10.1097/00004424-199207000-00013.
OBJECTIVES
Manganese (III) mesoporphyrin (Mn-mesoporphyrin), a synthetic and stable complex, was investigated for its hepatic magnetic resonance imaging (MRI) properties and compared with manganese tetrakis-(4 sulfonatophenyl) porphyrin (Mn-TPPS4).
METHODS
Liver abscesses (n = 10) and tumors (n = 14) were induced in rats. These rats then underwent MRI at 2.0 T. Animals received one of the two contrast agents, and measurement of lesion enhancement was performed.
RESULTS
At an intravenous dose of 0.035 mmol/kg, Mn-mesoporphyrin caused significant enhancement of normal liver parenchyma and increased the lesion-to-liver contrast in both the models of heptic liver abscess and metastatic liver disease. Mn-TTPS4 at an intravenous dose of 0.04 mmol/kg typically enhanced both lesion and normal liver parenchyma and therefore did not improve the lesion-to-liver contrast.
CONCLUSIONS
The hepatotrophic properties of Mn-mesoporphyrin indicate its potential as an intravenous contrast agent for liver imaging.
目的
研究合成的稳定复合物中卟啉锰（III）（Mn-中卟啉）的肝脏磁共振成像（MRI）特性，并与四（4-磺酸苯基）卟啉锰（Mn-TPPS4）进行比较。
方法
在大鼠中诱导肝脓肿（n = 10）和肿瘤（n = 14）。然后这些大鼠在2.0 T下接受MRI检查。动物接受两种造影剂之一，并进行病变增强测量。
结果
静脉注射剂量为0.035 mmol/kg时，Mn-中卟啉可使正常肝实质显著增强，并增加肝脓肿和转移性肝病模型中病变与肝脏的对比度。静脉注射剂量为0.04 mmol/kg的Mn-TTPS4通常会使病变和正常肝实质均增强，因此并未改善病变与肝脏的对比度。
结论
Mn-中卟啉的肝脏营养特性表明其作为肝脏成像静脉造影剂的潜力。
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