Rodgers D W
Ontario Hydro, Biological Research Section, Toronto, Canada.
Health Phys. 1992 Sep;63(3):331-7. doi: 10.1097/00004032-199209000-00009.
The contributions of tritiated water (3HHO) and dietary tritiated amino acids to the steady-state specific activities of tissue water tritium and organically bound tritium in mice were essentially independent and additive. Following exposure (56 d), organically bound tritium clearance was resolved into two distinct compartments. The first, with a half-life of 1-2 d, likely represented exchangeable organically bound tritium, and the second, with a half-life of 20-30 d, likely represented nonexchangeable organically bound tritium. Since organically bound tritium was cleared much more slowly than tissue water tritium, organically bound tritium was the principal determinant in estimated radiation doses to mice following exposure.
氚水（³HHO）和膳食中氚标记氨基酸对小鼠组织水氚和有机结合氚稳态比活度的贡献基本独立且具有加和性。暴露（56天）后，有机结合氚的清除被解析为两个不同的隔室。第一个隔室的半衰期为1 - 2天，可能代表可交换的有机结合氚，第二个隔室的半衰期为20 - 30天，可能代表不可交换的有机结合氚。由于有机结合氚的清除比组织水氚慢得多，因此有机结合氚是暴露后小鼠估计辐射剂量的主要决定因素。
