Qian Gouying, Xu Zirong
Faculty of Animal Science, Zhejiang University, Zhejiang 310007, China.
Bioresour Technol. 2007 Jan;98(1):202-6. doi: 10.1016/j.biortech.2005.12.004. Epub 2006 Jan 30.
The effect of the protein-bound polysaccharide extracted from Glaciecola polaris (PSG) was investigated in vitro in the protection of oxidatively-injured mouse macrophages stressed by tert-butyl hydroperoxide (tbOOH) or by oxidatively modified low-density lipoprotein (Ox-LDL). The results showed that PSG treatments to protect the macrophages from oxidative injury was effective and the macrophage colony-stimulating factor (M-CSF) exhibited some similar effects. It was speculated that both M-CSF and PSG could protect macrophages from oxidative injury. The results suggested that the effects of PSG were associated with its capability of inducing M-CSF expression.
研究了从极地嗜冷杆菌中提取的蛋白结合多糖（PSG）在体外对叔丁基过氧化氢（tbOOH）或氧化修饰低密度脂蛋白（Ox-LDL）应激的氧化损伤小鼠巨噬细胞的保护作用。结果表明，PSG处理对保护巨噬细胞免受氧化损伤是有效的，且巨噬细胞集落刺激因子（M-CSF）表现出一些相似的作用。据推测，M-CSF和PSG都可以保护巨噬细胞免受氧化损伤。结果提示，PSG的作用与其诱导M-CSF表达的能力有关。
