清醒状态下外侧膝状体核背侧部的丘脑爆发模式与注意力不集中

Thalamic burst mode and inattention in the awake LGNd.

作者信息

Bezdudnaya Tatiana, Cano Monica, Bereshpolova Yulia, Stoelzel Carl R, Alonso Jose-Manuel, Swadlow Harvey A

机构信息

Department of Psychology, University of Connecticut, Storrs, Connecticut 06269, USA.

出版信息

Neuron. 2006 Feb 2;49(3):421-32. doi: 10.1016/j.neuron.2006.01.010.

DOI:10.1016/j.neuron.2006.01.010

PMID:16446145

Abstract

Awake mammals are often inattentive in familiar environments, but must still respond appropriately to relevant visual stimulation. Such "inattentive vision" has received little study, perhaps due to difficulties in controlling eye position in this state. In rabbits, eye position is exceedingly stable in both alert and inattentive states. Here, we exploit this stability to examine temporal filtering of visual information in LGNd neurons as rabbits alternate between EEG-defined states. Within a single second of shifting from alert to an inattentive state, both peak temporal frequency and bandwidth were sharply reduced, and burst frequency increased dramatically. However, spatial dimensions of receptive field centers showed no significant state dependence. We conclude that extremely rapid and significant changes in temporal filtering and bursting occur in the LGNd as awake subjects shift between alert and inattentive states.

摘要

清醒的哺乳动物在熟悉的环境中常常注意力不集中，但仍必须对相关视觉刺激做出适当反应。这种“不注意视觉”很少受到研究，可能是因为在这种状态下控制眼球位置存在困难。在兔子身上，眼球位置在警觉和不注意状态下都极其稳定。在此，我们利用这种稳定性来研究当兔子在脑电图定义的状态之间转换时，LGNd神经元中视觉信息的时间滤波情况。从警觉状态转变为不注意状态的一秒内，峰值时间频率和带宽都急剧降低，而爆发频率则大幅增加。然而，感受野中心的空间维度没有表现出明显的状态依赖性。我们得出结论，当清醒的受试者在警觉和不注意状态之间转换时，LGNd中时间滤波和爆发会发生极其快速且显著的变化。