Hubert Christine, Savary Katia, Gasc Jean-Marie, Corvol Pierre
Collège de France, Paris.
Nat Clin Pract Cardiovasc Med. 2006 Feb;3(2):80-5. doi: 10.1038/ncpcardio0449.
The role of the renin-angiotensin system was previously thought to be restricted to the cardiovascular system. It now appears that this system also has important functions in other tissues. Hematopoiesis can be affected by inhibitors of the renin system in patients and in various experimental models. The renin system, particularly angiotensin II, has a role in different stages of hematopoiesis, notably during the first wave in the chick embryo (primitive hematopoiesis) and in the human adult (definitive hematopoiesis). In addition, the renin-angiotensin system in mice is involved in reconstitutive hematopoiesis following experimental irradiation; inhibition of this system improved the hematopoietic recovery in this situation. The clinical relevance and therapeutic applications of these findings offer a new area of clinical research. In this article, we review the evidence for a role for the renin system in the control of hematopoiesis at its different stages.
肾素-血管紧张素系统的作用以前被认为局限于心血管系统。现在看来，该系统在其他组织中也具有重要功能。在患者和各种实验模型中，造血功能会受到肾素系统抑制剂的影响。肾素系统，尤其是血管紧张素II，在造血的不同阶段发挥作用，特别是在鸡胚的第一波造血（原始造血）和人类成年人的造血（定型造血）过程中。此外，小鼠体内的肾素-血管紧张素系统参与了实验性照射后的造血重建；在这种情况下，抑制该系统可改善造血恢复。这些发现的临床相关性和治疗应用为临床研究提供了一个新领域。在本文中，我们综述了肾素系统在不同阶段控制造血过程中发挥作用的证据。
