基质细胞外蛋白和金属蛋白酶在头颈癌中的作用：最新综述
The role of matrix extracellular proteins and metalloproteinases in head and neck carcinomas: an updated review.
作者信息
Pereira Antonio L A, Veras Simone S L, Silveira Ericka J D, Seabra Flávio R G, Pinto Leão Pereira, Souza Lélia B, Freitas Roseana A
机构信息
Department of Dental Sciences, Federal University of Maranhão.
出版信息
Braz J Otorhinolaryngol. 2005 Jan-Feb;71(1):81-6. doi: 10.1016/s1808-8694(15)31289-1. Epub 2006 Jan 2.
Interactions involving tumor cells and the extracellular matrix (ECM) strongly influence tumor development, including head and neck tumors, affecting cell proliferation and survival as well as the ability to migrate beyond the original location into other tissues to form metastases. These cell migration is often facilitated by partial destruction of the surrounding ECM, which is catalyzed by matrix metalloproteinases (MMPs), a family of more than 20 endopeptidases that is controlled by regulated expression of specific inhibitors (TIMPs). Several studies of ECM and MMPs markers have provided additional diagnostic and prognostic information in head and neck carcinomas. In this review, we are considering the role of ECM and MMPs in tumor progression, emphasizing its proteolytic contributors to this process, and interactions between several members of ECM providing substrate to regulation of this process.
涉及肿瘤细胞与细胞外基质（ECM）的相互作用对肿瘤发展具有强烈影响，包括头颈肿瘤，影响细胞增殖、存活以及迁移至原始位置以外的其他组织形成转移灶的能力。这些细胞迁移通常由周围ECM的部分破坏所促进，这一过程由基质金属蛋白酶（MMPs）催化，MMPs是一个由20多种内肽酶组成的家族，受特定抑制剂（TIMPs）的调控表达控制。多项关于ECM和MMPs标志物的研究为头颈癌提供了额外的诊断和预后信息。在本综述中，我们探讨ECM和MMPs在肿瘤进展中的作用，强调其在这一过程中的蛋白水解作用，以及ECM的几个成员之间的相互作用如何为该过程的调控提供底物。
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