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Progress in Precision Medicine for Head and Neck Cancer.

作者信息

Vakili Sanaz, Behrooz Amir Barzegar, Whichelo Rachel, Fernandes Alexandra, Emwas Abdul-Hamid, Jaremko Mariusz, Markowski Jarosław, Los Marek J, Ghavami Saeid, Vitorino Rui

机构信息

Department of Human Anatomy and Cell Science, University of Manitoba College of Medicine, Winnipeg, MB R3E 0J9, Canada.

Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.

出版信息

Cancers (Basel). 2024 Nov 4;16(21):3716. doi: 10.3390/cancers16213716.

DOI:10.3390/cancers16213716
PMID:39518152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11544984/
Abstract

This paper presents a comprehensive comparative analysis of biomarkers for head and neck cancer (HNC), a prevalent but molecularly diverse malignancy. We detail the roles of key proteins and genes in tumourigenesis and progression, emphasizing their diagnostic, prognostic, and therapeutic relevance. Our bioinformatic validation reveals crucial genes such as AURKA, HMGA2, MMP1, PLAU, and SERPINE1, along with microRNAs (miRNA), linked to HNC progression. OncomiRs, including hsa-miR-21-5p, hsa-miR-31-5p, hsa-miR-221-3p, hsa-miR-222-3p, hsa-miR-196a-5p, and hsa-miR-200c-3p, drive tumourigenesis, while tumour-suppressive miRNAs like hsa-miR-375 and hsa-miR-145-5p inhibit it. Notably, hsa-miR-155-3p correlates with survival outcomes in addition to the genes RAI14, S1PR5, OSBPL10, and METTL6, highlighting its prognostic potential. Future directions should focus on leveraging precision medicine, novel therapeutics, and AI integration to advance personalized treatment strategies to optimize patient outcomes in HNC care.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c91/11544984/a705d3897b73/cancers-16-03716-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c91/11544984/a0d069dc21bf/cancers-16-03716-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c91/11544984/a705d3897b73/cancers-16-03716-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c91/11544984/a0d069dc21bf/cancers-16-03716-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c91/11544984/a705d3897b73/cancers-16-03716-g002.jpg

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Progress in Precision Medicine for Head and Neck Cancer.

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引用本文的文献

[1]
Dysregulated miRNA Expression and Its Association with Immune Checkpoints in Head and Neck Cancer.

Cancers (Basel). 2025-6-27

[2]
Matrix Dynamics and Microbiome Crosstalk: Matrix Metalloproteinases as Key Players in Disease and Therapy.

Int J Mol Sci. 2025-4-11

[3]
Beyond Genetics: Exploring Lifestyle, Microbiome, and Social Determinants in Oral Cancer Development.

Cancers (Basel). 2025-3-25

本文引用的文献

[1]
The Role of Biomarkers in HPV-Positive Head and Neck Squamous Cell Carcinoma: Towards Precision Medicine.

Diagnostics (Basel). 2024-7-7

[2]
Identification of candidate plasma miRNA biomarkers for the diagnosis of head and neck squamous cell carcinoma.

Future Sci OA. 2024-5-20

[3]
PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway.

Exp Cell Res. 2024-5-15

[4]
IP3R1 dysregulation via mir-200c-3p/SSFA2 axis contributes to taxol resistance in head and neck cancer.

Eur J Pharmacol. 2024-6-15

[5]
The Role of SOX2 and SOX9 in Radioresistance and Tumor Recurrence.

Cancers (Basel). 2024-1-19

[6]
miRNA in head and neck squamous cell carcinomas: promising but still distant future of personalized oncology.

Rep Pract Oncol Radiother. 2023-11-16

[7]
Fibronectin promotes tumor progression through integrin αvβ3/PI3K/AKT/SOX2 signaling in non-small cell lung cancer.

Heliyon. 2023-9-14

[8]
Regulation of microRNA by circular RNA.

Wiley Interdiscip Rev RNA. 2023-10-2

[9]
Survival associated miRNA signature in patients with head and neck carcinomas.

Heliyon. 2023-6-12

[10]
Epigenomic integrative analysis pinpoint master regulator transcription factors associated with tumorigenesis in squamous cell carcinoma of oral tongue.

Genet Mol Biol. 2023-6-19

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