Ito Kunihiko, Aono Akio, Yoshiyama Takashi, Wada Masako, Ogata Hideo
Department of Research, Research Institute of Tuberculosis, JATA, 3-1-24, Matsuyama, Kiyose-shi, Tokyo 204-8533, Japan.
Kekkaku. 2005 Dec;80(12):735-41.
Investigation on the influence of early start of chemotherapy on the results of sputum smear and culture (Ogawa medium and BACTEC MGIT960).
Retrospective study for tubercle bacilli positive pulmonary tuberculosis cases in our hospital.
Starting chemotherapy before the completion of pretreatment sputum examination was found to have no adverse effect on smear positive rate and smear positive grade (246 cases), culture contamination rate on Ogawa medium and BACTEC MGIT960 (1128 sputums), culture positive rate and culture positive grade/time to confirm positive on Ogawa medium (245 cases), and culture positive rate on BACTEC MGIT960 (239 cases). Time to confirm positive on BACTEC MGIT960 was slightly, but significantly prolonged (1.16 days delay in cases with 1-3 days chemotherapy [228 cases], and 4.01 days delay in cases with 4-6 days chemotherapy [59 cases]).
Unfluence of early start of chemotherapy on the results of sputum smear and culture is minor. In most of bacilli positive pulmonary tuberculosis cases chemotherapy can be started before the completion of pretreatment sputum examination.
研究早期开始化疗对痰涂片及培养结果（小川培养基和BACTEC MGIT960）的影响。
对我院结核杆菌阳性肺结核病例进行回顾性研究。
发现在预处理痰检查完成前开始化疗，对涂片阳性率及涂片阳性分级（246例）、小川培养基和BACTEC MGIT960上的培养污染率（1128份痰液）、小川培养基上的培养阳性率及培养阳性分级/确认阳性时间（245例）以及BACTEC MGIT960上的培养阳性率（239例）均无不良影响。BACTEC MGIT960上确认阳性的时间略有延长，但差异有统计学意义（化疗1 - 3天的病例延迟1.16天[228例]，化疗4 - 6天的病例延迟4.01天[59例]）。
早期开始化疗对痰涂片及培养结果的影响较小。在大多数结核杆菌阳性肺结核病例中，可在预处理痰检查完成前开始化疗。
