Develioğlu Hakan, Koptagel Emel, Gedik Rüştü, Dupoirieux Laurent
Department of Periodontology, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey.
J Oral Implantol. 2005;31(6):309-12. doi: 10.1563/1548-1336(2005)31[309:TEOABC]2.0.CO;2.
Bioactive ceramics (calcium phosphate ceramics, hydroxyapatite ceramics) are now extensively used in oral surgery. The purpose of this study was to assess the effect of a new biphasic ceramic (Ceraform) on the osteogenesis in a rat calvarial defect model. Fifteen Wistar rats were used in this study. Two symmetrical 3-mm wide defects were created in the skull of each rat. The left defect was left empty as a control and the right defect was filled with the ceramic. The rats were sacrificed at day 30, and the calvarial specimens were processed for qualitative and quantitative histological examinations. The material exhibited no adverse effects, but no bone healing was noted either. No statistical difference regarding bone regeneration was observed between the 2 defects (P > .05). This study showed that Ceraform did not elicit any inflammatory reaction; however, it had no effect on bone regeneration, and this material seems suitable only as a space-maintaining material.
生物活性陶瓷（磷酸钙陶瓷、羟基磷灰石陶瓷）目前广泛应用于口腔外科手术。本研究的目的是评估一种新型双相陶瓷（Ceraform）对大鼠颅骨缺损模型中成骨作用的影响。本研究使用了15只Wistar大鼠。在每只大鼠的颅骨上制造两个对称的3毫米宽的缺损。左侧缺损不做处理作为对照，右侧缺损填充陶瓷。在第30天处死大鼠，对颅骨标本进行定性和定量组织学检查。该材料未显示出不良反应，但也未观察到骨愈合。两个缺损之间在骨再生方面未观察到统计学差异（P>.05）。本研究表明，Ceraform未引发任何炎症反应；然而，它对骨再生没有作用，这种材料似乎仅适合作为一种维持空间的材料。
