低价铌介导的C-F/C-H键双活化：由邻芳基化α,α,α-三氟甲苯衍生物合成芴
Low-valent niobium-mediated double activation of C-F/C-H bonds: fluorene synthesis from o-arylated alpha,alpha,alpha-trifluorotoluene derivatives.
作者信息
Fuchibe Kohei, Akiyama Takahiko
机构信息
Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
出版信息
J Am Chem Soc. 2006 Feb 8;128(5):1434-5. doi: 10.1021/ja0565323.
PMID:16448098
Abstract
By the treatment of 0.3 molar amount of NbCl5 and LiAlH4, o-arylated alpha,alpha,alpha-trifluorotoluenes afforded fluorene derivatives in good yields. C-F bonds of the CF3 group and the neighboring ortho C-H bond were doubly activated to give the coupling products.
摘要
通过用0.3摩尔量的五氯化铌和氢化铝锂处理，邻芳基化的α,α,α-三氟甲苯以良好的产率得到芴衍生物。CF3基团的C-F键和相邻的邻位C-H键被双重活化以得到偶联产物。
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