低价铌催化的α,α,α-三氟甲苯的还原反应
Low-valent niobium-catalyzed reduction of alpha,alpha,alpha-trifluorotoluenes.
作者信息
Fuchibe Kohei, Ohshima Yoshitaka, Mitomi Ken, Akiyama Takahiko
机构信息
Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro Toshima-ku, Tokyo 171-8588, Japan.
出版信息
Org Lett. 2007 Apr 12;9(8):1497-9. doi: 10.1021/ol070249m. Epub 2007 Mar 13.
PMID:17352487
Abstract
[reaction: see text] In the presence of 5 mol % of niobium(V) chloride, alpha,alpha,alpha-trifluorotoluene derivatives were reduced with lithium aluminum hydride to give toluene derivatives in good yields. Stepwise, partial reduction of bis(trifluoromethyl)benzene derivative was also demonstrated.
摘要
[反应：见正文] 在5摩尔%的五氯化铌存在下，α,α,α-三氟甲苯衍生物用氢化铝锂还原，以良好的产率得到甲苯衍生物。还证明了双（三氟甲基）苯衍生物的逐步部分还原。
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