Duncan Colleen G, Stephen Craig, Campbell John
Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada.
J Am Vet Med Assoc. 2006 Feb 1;228(3):377-82. doi: 10.2460/javma.228.3.377.
To determine risk factors associated with Cryptococcus gattii infection in dogs and cats residing on Vancouver Island in British Columbia, Canada.
Matched case-control study.
20 dogs and 29 cats with C gattii infection and matched controls.
Dogs and cats with a confirmed or probable diagnosis of cryptococcosis resulting from infection with C gattii were enrolled by veterinarians, and owners completed a questionnaire designed to obtain information pertaining to potential risk factors for the disease. Owners of matched control animals were also interviewed. Odds ratios and 95% confidence intervals or paired t tests were calculated to determine significant associations.
Animals were enrolled during 2 noncontiguous periods in August 2001 to February 2002 (8 dogs and 9 cats enrolled) and May to December 2003 (12 dogs and 20 cats enrolled). Risk factors significantly associated with development of cryptococcosis included residing within 10 km of a logging site or other area of commercial soil disturbance, above-average level of activity of the animal, travelling of the animal on Vancouver Island, hunting by the animal, and owners hiking or visiting a botanic garden.
Results indicated that dogs and cats that were active or that lived near a site of commercial environmental disturbance had a significantly increased risk of developing C gattii infection. Veterinarians should communicate these risks to owners in context because cryptococcosis was an uncommon disease in this population.
确定加拿大不列颠哥伦比亚省温哥华岛上感染加氏隐球菌的犬猫的相关危险因素。
配对病例对照研究。
20只感染加氏隐球菌的犬和29只感染加氏隐球菌的猫以及配对对照。
兽医招募确诊或疑似由加氏隐球菌感染引起隐球菌病的犬猫，其主人填写一份旨在获取与该疾病潜在危险因素相关信息的问卷。也对配对对照动物的主人进行访谈。计算比值比和95%置信区间或配对t检验以确定显著关联。
动物在2001年8月至2002年2月的2个不连续时间段（招募8只犬和9只猫）以及2003年5月至12月（招募12只犬和20只猫）被纳入研究。与隐球菌病发生显著相关的危险因素包括居住在距离伐木场或其他商业性土壤扰动区域10公里以内、动物活动水平高于平均水平、动物在温哥华岛旅行、动物捕猎以及主人徒步旅行或参观植物园。
结果表明，活跃的或生活在商业环境扰动区域附近的犬猫感染加氏隐球菌的风险显著增加。兽医应结合实际情况将这些风险告知主人，因为隐球菌病在该群体中是一种罕见疾病。
