Duncan C, Stephen C, Lester S, Bartlett K H
Department of Large Animal Clinical Sciences, WCVM, University of Saskatchewan, Saskatoon, Canada.
Med Mycol. 2005 Sep;43(6):511-6. doi: 10.1080/13693780500036019.
Since 1999, Cryptococcus gattii has emerged as an important pathogen of humans and animals in British Columbia, Canada. Nasal swabs and serum samples were collected from dogs and cats residing within the Coastal Douglas Fir biogeoclimatic zone on Vancouver Island, where clinical cases have been reported. Deep and superficial nasal fungal cultures of 280 dogs and 94 cats identified four (4.3%) cats and three (1.1%) dogs with C. gattii serotype B in their nasal cavity. Serum samples collected from 266 dogs and 84 cats identified six (7.1%) cats and two (0.8%) dogs with a positive cryptococcal antigen titer. Overall cats were 4.4 times more likely than dogs to be positive on one or both tests. Identification of sub-clinical infection and nasal colonization is an important step in the characterization of the outbreak of clinical cryptococcosis on Vancouver Island.
自1999年以来，加氏隐球菌已成为加拿大不列颠哥伦比亚省人和动物的重要病原体。从居住在温哥华岛沿海花旗松生物地理气候区的犬猫身上采集鼻拭子和血清样本，该地区已报告有临床病例。对280只犬和94只猫进行鼻腔深部和浅表真菌培养，发现4只（4.3%）猫和3只（1.1%）犬鼻腔中有B型加氏隐球菌。从266只犬和84只猫采集的血清样本中，发现6只（7.1%）猫和2只（0.8%）犬的隐球菌抗原滴度呈阳性。总体而言，猫在一项或两项检测中呈阳性的可能性是犬的4.4倍。识别亚临床感染和鼻腔定植是温哥华岛临床隐球菌病暴发特征描述的重要一步。
