新型隐球菌：一种感染人类和动物的新兴真菌病原体。
Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals.
机构信息
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
出版信息
Microbes Infect. 2011 Oct;13(11):895-907. doi: 10.1016/j.micinf.2011.05.009. Epub 2011 Jun 1.
Abstract
Infectious fungi are among a broad group of microbial pathogens that has and continues to emerge concomitantly due to the global AIDS pandemic as well as an overall increase of patients with compromised immune systems. In addition, many pathogens have been emerging and re-emerging, causing disease in both individuals who have an identifiable immune defect and those who do not. The fungal pathogen Cryptococcus gattii can infect individuals with and without an identifiable immune defect, with a broad geographic range including both endemic areas and emerging outbreak regions. Infections in patients and animals can be severe and often fatal if untreated. We review the molecular epidemiology, population structure, clinical manifestations, and ecological niche of this emerging pathogen.
摘要
传染性真菌是广泛的微生物病原体之一，由于全球艾滋病流行以及免疫系统受损患者数量的总体增加，它们不断同时出现。此外，许多病原体已经出现并再次出现，导致有明确免疫缺陷的个体和没有免疫缺陷的个体患病。真菌病原体荚膜组织胞浆菌可以感染有和没有明确免疫缺陷的个体，其地理范围广泛，包括地方性地区和新出现的暴发地区。如果未经治疗，患者和动物的感染可能很严重，并且常常是致命的。我们回顾了这种新兴病原体的分子流行病学、种群结构、临床表现和生态位。
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