Turan Hale, Balci Ugur, Erdinc F Sebnem, Tulek Necla, Germiyanoglu Cankon
Ankara Training and Research Hospital Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey.
Int J Urol. 2006 Jan;13(1):25-8. doi: 10.1111/j.1442-2042.2006.01219.x.
The assumed necessity of antimicrobial prophylaxis prior to cystoscopy is controversial. In this study, the rate of bacteriuria, pyuria and bacteremia in outpatients who underwent cystoscopy without antimicrobial prophylaxis is investigated prospectively.
The study included 75 patients who underwent cystoscopy for various indications and had sterile urine prior to intervention. A clean midstream urine sample was obtained 24 h before and 48 h after the procedure. Blood cultures were taken 1 h after cystoscopy. Patients were questioned for newly developed symptoms 48 h after cystoscopy. Blood cultures were taken again from patients who presented with fever.
Six patients (8%) developed significant bacteriuria, and six patients (8%) developed pyuria without significant bacteriuria. Bacteremia was not determined in any of the patients. The association between presence of pyuria prior to the procedure and development of bacteriuria after the procedure was significant (P < 0.05). Four patients out of six who had bacteriuria were asymptomatic. In our study we found significant bacteriuria after cystoscopy in 8% of patients, and no bacteremia.
Thus we conclude that cystoscopy is a safe and well-tolerated procedure. Antimicrobial prophylaxis should not be administrated unless specific indications are present.
膀胱镜检查前使用抗菌药物预防的必要性存在争议。本研究前瞻性调查了未进行抗菌药物预防的门诊患者膀胱镜检查后的菌尿症、脓尿症和菌血症发生率。
该研究纳入了75例因各种适应证接受膀胱镜检查且干预前尿液无菌的患者。在检查前24小时和检查后48小时采集清洁中段尿样本。膀胱镜检查后1小时采集血培养样本。在膀胱镜检查后48小时询问患者是否出现新症状。对发热患者再次采集血培养样本。
6例患者(8%)出现显著菌尿症,6例患者(8%)出现脓尿症但无显著菌尿症。所有患者均未检测到菌血症。检查前存在脓尿症与检查后发生菌尿症之间的关联具有显著性(P<0.05)。6例菌尿症患者中有4例无症状。在我们的研究中,8%的患者在膀胱镜检查后出现显著菌尿症,未发现菌血症。
因此我们得出结论,膀胱镜检查是一种安全且耐受性良好的检查方法。除非有特定指征,否则不应进行抗菌药物预防。