Reddy Peddyreddy Murali Krishna, Dkhar Steven Aibor, Subramanian Ramaswamy
Department of Pharmacology, JIPMER, Pondicherry-605006, India.
BMC Pharmacol. 2006 Feb 1;6:4. doi: 10.1186/1471-2210-6-4.
Insulin is the drug of choice in the management of diabetes mellitus (DM). About 76 % of diabetic patients suffer from gastrointestinal (GI) disorders. Therapy of DM with insulin primarily involves lowering of elevated blood glucose levels. Hence, on any organ in addition to insulin's effect, hypoglycaemic effect also prevails. A systematic study exploring the effect of insulin on small intestinal transit in normal laboratory animals is lacking. Hence, in the present study, the possible effect of insulin with or without associated hypoglycaemia on small intestinal transit in normal mice was examined.
Insulin in all the doses tested (2 mu, 2 m and 2 U/kg) elicited a significant acceleration of SIT. The lower doses of insulin (2 mu and 2 m U/kg) produced significant acceleration of SIT and were associated with normal blood glucose levels. However, the highest dose of insulin (2 U/kg) produced an acceleration of SIT that was associated with significant fall in blood glucose levels. Further, the 2 m and 2 U doses of insulin significantly elevated serum insulin and C-peptide levels.
Insulin at the lowest dose produced an acceleratory effect on SIT that was independent of blood glucose and serum insulin levels in normal mice.
胰岛素是治疗糖尿病（DM）的首选药物。约76%的糖尿病患者患有胃肠道（GI）疾病。胰岛素治疗糖尿病主要涉及降低升高的血糖水平。因此，除了胰岛素的作用外，低血糖作用在任何器官中也普遍存在。缺乏一项系统研究来探索胰岛素对正常实验动物小肠转运的影响。因此，在本研究中，研究了有或无相关低血糖的胰岛素对正常小鼠小肠转运的可能影响。
所有测试剂量（2微克、2毫微克和2单位/千克）的胰岛素均显著加速了小肠转运（SIT）。较低剂量的胰岛素（2微克和2毫微克/千克）显著加速了SIT，且与正常血糖水平相关。然而，最高剂量的胰岛素（2单位/千克）加速了SIT，且与血糖水平显著下降相关。此外，2毫微克和2单位剂量的胰岛素显著提高了血清胰岛素和C肽水平。
最低剂量的胰岛素对正常小鼠的SIT产生加速作用，且与血糖和血清胰岛素水平无关。
