重复经颅磁刺激对耐药性抑郁症患者血清脑源性神经营养因子的影响
Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in drug resistant depressed patients.
作者信息
Zanardini Roberta, Gazzoli Anna, Ventriglia Mariacarla, Perez Jorge, Bignotti Stefano, Rossini Paolo Maria, Gennarelli Massimo, Bocchio-Chiavetto Luisella
机构信息
IRCCS "S. Giovanni di Dio", Fatebenefratelli, Brescia, Italy.
出版信息
J Affect Disord. 2006 Mar;91(1):83-6. doi: 10.1016/j.jad.2005.12.029. Epub 2006 Jan 31.
BACKGROUND
Depression has been associated with low brain-derived neurotrophic factor (BDNF) serum levels, while antidepressant drugs appear to mend this alteration. The purpose of this study was to assess BDNF serum levels in drug resistant depressed patients before and after repetitive Transcranial Magnetic Stimulation (rTMS) antidepressant treatment.
METHODS
BDNF levels were measured in serum of 16 resistant depressed patients using the ELISA technique.
RESULTS
BDNF baseline levels showed a negative correlation with illness severity measured by HDRS scores (R = -0.517, p = 0.04) and a significant increase of serum BDNF was found after rTMS treatment (t = -2.549, df = 15, p = 0.022).
CONCLUSIONS
Our findings support the relationship between decreased serum BDNF and depression symptomatology and suggest a normalizing effect of rTMS antidepressant treatment. Further replications in larger samples will help to clarify the relevance of this preliminary data in the rTMS mechanism of action.
背景
抑郁症与血清脑源性神经营养因子（BDNF）水平降低有关，而抗抑郁药物似乎能纠正这种改变。本研究的目的是评估难治性抑郁症患者在重复经颅磁刺激（rTMS）抗抑郁治疗前后的血清BDNF水平。
方法
采用ELISA技术检测16例难治性抑郁症患者血清中的BDNF水平。
结果
BDNF基线水平与用汉密尔顿抑郁量表（HDRS）评分衡量的疾病严重程度呈负相关（R = -0.517，p = 0.04），且rTMS治疗后血清BDNF显著升高（t = -2.549，自由度 = 15，p = 0.022）。
结论
我们的研究结果支持血清BDNF降低与抑郁症状之间的关系，并提示rTMS抗抑郁治疗具有归一化作用。在更大样本中进一步重复研究将有助于阐明这些初步数据在rTMS作用机制中的相关性。
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