选择性环氧化酶-2抑制剂与S-1联合应用对胃硬癌细胞腹膜转移的协同抑制作用。

A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells.

作者信息

Tendo Masashige, Yashiro Masakazu, Nakazawa Kazunori, Yamada Nobuya, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei

机构信息

Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.

出版信息

Cancer Lett. 2006 Dec 8;244(2):247-51. doi: 10.1016/j.canlet.2005.12.019. Epub 2006 Jan 31.

DOI:10.1016/j.canlet.2005.12.019

PMID:16448745

Abstract

An inhibitory-effect of a selective cyclooxygenase-2 (COX-2) inhibitor on peritoneal metastasis of scirrhous gastric carcinoma was investigated in vivo. Peritoneal metastasis had developed after intraperitoneal inoculation of scirrhous gastric cancer cells, OCUM-2MD3, in nude mice. COX-2 inhibitor and/or S-1 were administered orally in nude mice with peritoneal metastasis. Oral administration of COX-2 inhibitor and S-1 significantly prolonged survival rates of these nude mice, compared with either alone. These findings suggested that combining S-1 and COX-2 inhibitor administration obtain a synergistic inhibitory-effect on the peritoneal metastasis of scirrhous gastric carcinoma.

摘要

在体内研究了选择性环氧化酶-2（COX-2）抑制剂对硬癌性胃癌腹膜转移的抑制作用。在裸鼠腹腔内接种硬癌性胃癌细胞OCUM-2MD3后发生了腹膜转移。对发生腹膜转移的裸鼠口服给予COX-2抑制剂和/或S-1。与单独使用相比，口服给予COX-2抑制剂和S-1可显著延长这些裸鼠的存活率。这些发现表明，联合给予S-1和COX-2抑制剂对硬癌性胃癌的腹膜转移具有协同抑制作用。