硬癌性胃癌中的癌-基质相互作用
Cancer-stromal interactions in scirrhous gastric carcinoma.
作者信息
Yashiro Masakazu, Hirakawa Kosei
出版信息
Cancer Microenviron. 2010 Jan 26;3(1):127-35. doi: 10.1007/s12307-010-0036-5.
Abstract
Fibroblasts play an important role in the progression, growth and spread of gastric cancers. Cancer-stroma interactions have been especially evident in the scirrhous type of gastric carcinoma. Fibroblasts are associated with the cancer progression at the primary and metastatic site. The proliferative and invasive ability of scirrhous gastric cancer cells are closely associated with the growth factors produced by organ-specific fibroblasts. Fibroblasts are therefore a key determinant in the malignant progression of gastric cancer and represent an important target for cancer therapies.
摘要
成纤维细胞在胃癌的进展、生长和扩散中发挥着重要作用。癌-基质相互作用在硬癌型胃癌中尤为明显。成纤维细胞与原发性和转移部位的癌症进展相关。硬癌型胃癌细胞的增殖和侵袭能力与器官特异性成纤维细胞产生的生长因子密切相关。因此，成纤维细胞是胃癌恶性进展的关键决定因素，也是癌症治疗的重要靶点。
相似文献
1
Cancer-stromal interactions in scirrhous gastric carcinoma.硬癌性胃癌中的癌-基质相互作用
Cancer Microenviron. 2010 Jan 26;3(1):127-35. doi: 10.1007/s12307-010-0036-5.
2
[Pathogenesis and progression of scirrhous carcinoma].[硬癌的发病机制与进展]
Gan To Kagaku Ryoho. 1994 Oct;21(14):2364-70.
3
[Mechanisms responsible for the progression of scirrhous gastric cancer].[硬癌性胃癌进展的相关机制]
Nihon Rinsho. 2012 Oct;70(10):1812-6.
4
Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts.硬癌和高分化胃癌细胞对原位成纤维细胞的不同反应
Br J Cancer. 1996 Oct;74(7):1096-103. doi: 10.1038/bjc.1996.496.
5
6
Role of orthotopic fibroblasts in the development of scirrhous gastric carcinoma.原位成纤维细胞在硬癌型胃癌发生中的作用
Jpn J Cancer Res. 1994 Sep;85(9):883-6. doi: 10.1111/j.1349-7006.1994.tb02963.x.
7
Myofibroblasts are associated with the progression of scirrhous gastric carcinoma.肌成纤维细胞与硬癌型胃癌的进展相关。
Exp Ther Med. 2010 Jul;1(4):547-551. doi: 10.3892/etm_00000086. Epub 2010 Jul 1.
8
9
Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma.选择性环氧化酶-2抑制剂下调硬癌型胃癌生长中旁分泌的上皮-间质相互作用。
Int J Cancer. 2007 Feb 1;120(3):686-93. doi: 10.1002/ijc.22329.
10
Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-β signaling.癌相关成纤维细胞可能通过转化生长因子-β信号维持硬癌胃癌细胞的干性。
Int J Cancer. 2014 Apr 15;134(8):1785-95. doi: 10.1002/ijc.28520. Epub 2013 Oct 24.
引用本文的文献
1
Molecular Mechanism for Malignant Progression of Gastric Cancer Within the Tumor Microenvironment.肿瘤微环境中胃癌恶性进展的分子机制。
Int J Mol Sci. 2024 Oct 31;25(21):11735. doi: 10.3390/ijms252111735.
2
Prognostic significance of connective tissue growth factor expression in stromal cells in patients with diffuse‑type gastric cancer.结缔组织生长因子在弥漫型胃癌患者基质细胞中的表达的预后意义
Oncol Lett. 2024 Apr 3;27(6):241. doi: 10.3892/ol.2024.14374. eCollection 2024 Jun.
3
The Role of the Transforming Growth Factor-β Signaling Pathway in Gastrointestinal Cancers.转化生长因子-β 信号通路在胃肠道癌症中的作用。
Biomolecules. 2023 Oct 19;13(10):1551. doi: 10.3390/biom13101551.
4
CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation.CD142 鉴定肿瘤性成纤维细胞源性肿瘤细胞，揭示驱动增殖的肿瘤细胞与基质细胞之间的相互作用。
Cancer Res Commun. 2023 Apr 25;3(4):697-708. doi: 10.1158/2767-9764.CRC-22-0403. eCollection 2023 Apr.
5
Integrated single-cell and bulk RNA sequencing analysis identifies a cancer-associated fibroblast-related gene signature for predicting survival and therapy in gastric cancer.单细胞和 bulk RNA 测序分析整合鉴定出一个与癌症相关的成纤维细胞相关基因特征，可用于预测胃癌患者的生存和治疗反应。
BMC Cancer. 2023 Jan 31;23(1):108. doi: 10.1186/s12885-022-10332-w.
6
Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica.原发性胃皮革胃的全面转录组谱分析和突变特征。
Gastric Cancer. 2023 Mar;26(2):203-219. doi: 10.1007/s10120-022-01353-2. Epub 2022 Nov 30.
7
The heterogeneity of cancer-associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment.癌症相关成纤维细胞亚群的异质性：它们的起源、生物标志物及其在肿瘤微环境中的作用。
Cancer Sci. 2023 Jan;114(1):16-24. doi: 10.1111/cas.15609. Epub 2022 Oct 19.
8
Receptor Tyrosine Kinases Amplified in Diffuse-Type Gastric Carcinoma: Potential Targeted Therapies and Novel Downstream Effectors.弥漫型胃癌中扩增的受体酪氨酸激酶：潜在的靶向治疗和新型下游效应器
Cancers (Basel). 2022 Aug 1;14(15):3750. doi: 10.3390/cancers14153750.
9
Gastric cancer multicellular spheroid analysis by two-photon microscopy.通过双光子显微镜对胃癌多细胞球体进行分析。
Biomed Opt Express. 2022 Apr 28;13(5):3120-3130. doi: 10.1364/BOE.450518. eCollection 2022 May 1.
10
Cancer-associated fibroblasts-derived HAPLN1 promotes tumour invasion through extracellular matrix remodeling in gastric cancer.癌症相关成纤维细胞衍生的 HAPLN1 通过重塑胃癌细胞外基质促进肿瘤侵袭。
Gastric Cancer. 2022 Mar;25(2):346-359. doi: 10.1007/s10120-021-01259-5. Epub 2021 Nov 1.
本文引用的文献
1
Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model.VEGFR-3磷酸化抑制剂对原位弥漫型胃癌模型淋巴结转移的影响
Br J Cancer. 2009 Oct 6;101(7):1100-6. doi: 10.1038/sj.bjc.6605296.
2
Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma.成纤维细胞生长因子受体 2 抑制剂与氟尿嘧啶联合应用对硬纤维瘤胃癌的协同抗肿瘤作用。
Int J Cancer. 2010 Feb 15;126(4):1004-16. doi: 10.1002/ijc.24763.
3
Hereditary diffuse gastric cancer: a manifestation of lost cell polarity.遗传性弥漫性胃癌：细胞极性丧失的一种表现。
Cancer Sci. 2009 Jul;100(7):1151-7. doi: 10.1111/j.1349-7006.2009.01163.x. Epub 2009 Apr 21.
4
Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer.选择性杀伤缺氧诱导因子-1活性细胞可提高侵袭性和转移性胰腺癌小鼠模型的生存率。
Clin Cancer Res. 2009 May 15;15(10):3433-41. doi: 10.1158/1078-0432.CCR-08-2267. Epub 2009 May 5.
5
Recent results of therapy for scirrhous gastric cancer.硬癌性胃癌的近期治疗结果
Surg Today. 2009;39(4):290-4. doi: 10.1007/s00595-008-3860-1. Epub 2009 Mar 25.
6
Abnormal growth factor/cytokine network in gastric cancer.胃癌中异常的生长因子/细胞因子网络
Cancer Microenviron. 2008 Dec;1(1):85-91. doi: 10.1007/s12307-008-0008-1. Epub 2008 Mar 19.
7
The metastatic niche: adapting the foreign soil.转移微环境：适应异质土壤
Nat Rev Cancer. 2009 Apr;9(4):285-93. doi: 10.1038/nrc2621.
8
Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma.角质形成细胞生长因子与K-sam的共表达是胃癌的一个独立预后因素。
Oncol Rep. 2009 Apr;21(4):875-80. doi: 10.3892/or_00000297.
9
Microenvironmental regulation of metastasis.转移的微环境调节
Nat Rev Cancer. 2009 Apr;9(4):239-52. doi: 10.1038/nrc2618. Epub 2008 Mar 12.
10
Stromal myofibroblasts are drivers of invasive cancer growth.基质肌成纤维细胞是侵袭性癌症生长的驱动因素。
Int J Cancer. 2008 Nov 15;123(10):2229-38. doi: 10.1002/ijc.23925.
Zotero 插件