Fell Deshayne B, Dodds Linda, Joseph K S, Allen Victoria M, Butler Blair
Perinatal Epidemiology Research Unit, Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, Nova Scotia, Canada.
Obstet Gynecol. 2006 Feb;107(2 Pt 1):277-84. doi: 10.1097/01.AOG.0000195059.82029.74.
To identify risk factors for hyperemesis requiring hospital admission during pregnancy.
Data from a population-based cohort of all deliveries in Nova Scotia, Canada between 1988 and 2002 were obtained from the Nova Scotia Atlee Perinatal Database. Women with 1 or more antepartum admissions for hyperemesis were compared with women with no admissions for hyperemesis. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using logistic regression and used to determine a set of independent risk factors for hyperemesis.
The overall rate of admission for hyperemesis was 0.8% (n = 1,301) among 157,922 deliveries. In the adjusted analysis, hyperthyroid disorders (RR 4.5, 95% CI 1.8-11.1), psychiatric illness (RR 4.1, 95% CI 3.0-5.7), previous molar pregnancy (RR 3.3, 95% CI 1.6-6.8), preexisting diabetes (RR 2.6, 95% CI 1.5-4.7), gastrointestinal disorders (RR 2.5, 95% CI 1.8-3.6), and asthma (RR 1.5, 95% CI 1.2-1.9) were all statistically significant risk factors for hyperemesis, whereas maternal smoking and maternal age older than 30 were associated with decreased risk. Compared with singleton male pregnancies, singleton female pregnancies, pregnancies with multiple male fetuses, and male and female combinations were associated with statistically significant increased risk of hyperemesis.
Although hospitalization for hyperemesis occurs in less than 1% of pregnant women, this translates to a large number of hospital admissions. The factors associated with hyperemesis are primarily medical and fetal factors that are not easily modifiable, but identification of these factors may be useful in determining those women at high risk for developing hyperemesis.
II-2.
确定孕期发生需要住院治疗的妊娠剧吐的危险因素。
从加拿大新斯科舍省阿特利围产期数据库获取1988年至2002年间新斯科舍省所有分娩的基于人群队列的数据。将有1次或更多次因妊娠剧吐而产前住院的妇女与无妊娠剧吐住院的妇女进行比较。使用逻辑回归估计相对风险（RRs）和95%置信区间（CIs），并用于确定一组妊娠剧吐的独立危险因素。
在157,922例分娩中，妊娠剧吐的总体住院率为0.8%（n = 1,301）。在调整分析中，甲状腺功能亢进症（RR 4.5，95% CI 1.8 - 11.1）、精神疾病（RR 4.1，95% CI 3.0 - 5.7）、既往葡萄胎妊娠（RR 3.3，95% CI 1.6 - 6.8）、孕前糖尿病（RR 2.6，95% CI 1.5 - 4.7）、胃肠道疾病（RR 2.5，95% CI 1.8 - 3.6）和哮喘（RR 1.5，95% CI 1.2 - 1.9）均为妊娠剧吐的统计学显著危险因素，而孕妇吸烟和孕妇年龄大于30岁与风险降低相关。与单胎男性妊娠相比，单胎女性妊娠、多胎男性胎儿妊娠以及男性和女性组合的妊娠剧吐风险均有统计学显著增加。
尽管妊娠剧吐住院发生率不到1%的孕妇，但这意味着大量的住院病例。与妊娠剧吐相关的因素主要是不易改变的医学和胎儿因素，但识别这些因素可能有助于确定那些发生妊娠剧吐高危的女性。
II - 2。
