DeUgarte Catherine Marin, Woods K S, Bartolucci Alfred A, Azziz Ricardo
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West Third Street, Suite 160 W, Los Angeles, CA 90048, USA.
J Clin Endocrinol Metab. 2006 Apr;91(4):1345-50. doi: 10.1210/jc.2004-2301. Epub 2006 Jan 31.
Hirsutism (i.e. facial and body terminal hair growth in a male-like pattern in women) is the principal clinical sign of hyperandrogenism, although its definition remains unclear.
The purposes of the present study were to define 1) the degree of facial and body terminal hair, as assessed by the modified Ferriman-Gallwey (mFG) score, in unselected women from the general population; 2) the effect of race (Black and White) on the same; and 3) the normative cutoff values.
We conducted a prospective observational study at a tertiary academic medical center.
PATIENTS/PARTICIPANTS: Participants included 633 unselected White (n = 283) and Black (n = 350) women presenting for a preemployment physical exam.
Interventions included history and physical examination.
Terminal body hair growth was assessed using the mFG scoring system; nine body areas were scored from 0-4 for terminal hair growth distribution.
The mFG scores were not normally distributed; although cluster analysis failed to identify a natural cutoff value or clustering of the population, principal component and univariate analyses denoted two nearly distinct clusters that occurred above and below an mFG value of 2, with the bulk of the scores below. Overall, an mFG score of at least 3 was observed in 22.1% of all subjects (i.e. the upper quartile); of these subjects, 69.3% complained of being hirsute, compared with 15.8% of women with an mFG score below this value, and similar to the proportion of women with an mFG score of at least 8 who considered themselves to be hirsute (70.0%). Overall, there were no significant differences between Black and White women.
Our data indicate that the prevalence and degree of facial and body terminal hair growth, as assessed by the mFG score, is similar in Black and White women and that an mFG of at least 3 signals the population of women whose hair growth falls out of the norm.
多毛症（即女性面部和身体出现类似男性的终毛生长模式）是高雄激素血症的主要临床体征，但其定义仍不明确。
本研究的目的是确定：1）通过改良的费里曼-盖尔维（mFG）评分评估的普通人群中未筛选女性的面部和身体终毛程度；2）种族（黑人和白人）对其的影响；3）正常临界值。
我们在一家三级学术医疗中心进行了一项前瞻性观察研究。
患者/参与者：参与者包括633名未筛选的前来进行入职前体检的白人（n = 283）和黑人（n = 350）女性。
干预措施包括病史采集和体格检查。
使用mFG评分系统评估身体终毛生长情况；对九个身体部位的终毛生长分布从0至4进行评分。
mFG评分不呈正态分布；尽管聚类分析未能确定自然临界值或人群聚类，但主成分分析和单变量分析表明，在mFG值为2以上和以下出现了两个几乎不同的聚类，大部分评分低于该值。总体而言，所有受试者中有22.1%（即上四分位数）的mFG评分至少为3；在这些受试者中，69.3%抱怨有多毛症，而mFG评分低于此值的女性中这一比例为15.8%，这与mFG评分至少为8且认为自己多毛的女性比例（70.0%）相似。总体而言，黑人和白人女性之间没有显著差异。
我们的数据表明，通过mFG评分评估，黑人和白人女性面部和身体终毛生长的患病率和程度相似，且mFG至少为3表明女性的毛发生长超出正常范围。
