Wong Meifong, Zhao Xiaomiao, Hong Yu, Yang Dongzi
Endokrynol Pol. 2014;65(5):365-70. doi: 10.5603/EP.2014.0050.
There is considerable individual and racial variation in the degree and pattern of body hair among PCOS patients. The purposes of this study were to define: 1) a suitable standard of hirsutism for Chinese women with PCOS and the general Chinese population; 2) the characteristics of hair distribution and degree in Chinese women with PCOS and the general population; and 3) the correlation of PCOS and FG score in Chinese women.
This retrospective study in Chinese women with PCOS in the reproductive centre of Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, comprised 850 patients with PCOS and 2,988 members of the general population. It was conducted crosssectionally by interview, physical examination, ultrasound scan, and modified Ferriman-Gallwey score. Eight hundred and fifty Chinese women with PCOS (aged 20-41) underwent an interview, blood drawing, physical and ultrasound examination. Body hair at nine sites (lip, chin, arm, thigh, chest, upper belly, lower belly, upper back and lower back) were evaluated using the scoring system described by Ferriman and Gallwey; 2,988 healthy women (aged 20-45) underwent an interview, physical examination, ultrasound scan and FG score evaluation by trained gynaecologists. Terminal body hair growth was assessed using the mFG scoring system in Chinese women with PCOS and the control group; nine body areas were scored from 0-4 for terminal hair growth distribution.
Our findings showed that of the 850 patients, 367 had a FG score equal to or greater than 5 points [43.2% (367/850)], 282 patients had a FG score equal to or greater than 6 points [33.18% (282/850)], and 21% had a score of at least 8 points. Nobody's FG score was equal to or greater than 24 points. Hirsutism was significantly higher in PCOS patients (score ≥ 5 = 43.2%) than in the general population (score ≥ 5 = 10%). The lip is the most common place (score 0-3) where terminal hair grows in 850 PCOS patients and the general population. Next came the upper back and chest, and the number of 4 points was only recorded for the region of the lip (16), thigh (3), lower belly (3), arm (1), chest (1), and lower back (1). None of the PCOS patients displayed a score of more than 4 points for the chin, upper belly and upper back.
Our data indicates that: 1) an mFG score of 5 or above is out of the norm for the general unselected population and forms almost half of the possibility of diagnosing PCOS in Chinese women; 2) lips and upper back are the most common places that hair grows (score 1-2), but in terms of the serious situation (score 3-4), lips and thighs are the most common places that hair grows; 3) there is a good predictive value to diagnose PCOS by FG score for Chinese people; and 4) hirsutism is more common in PCOS than in the general population in China.
多囊卵巢综合征（PCOS）患者的体毛程度和分布模式存在显著的个体和种族差异。本研究的目的是确定：1）适合中国PCOS女性及一般中国人群的多毛症标准；2）中国PCOS女性和一般人群的毛发分布特征及程度；3）中国女性PCOS与Ferriman-Gallwey（FG）评分的相关性。
本回顾性研究纳入了中山大学孙逸仙纪念医院生殖中心的850例PCOS中国女性患者和2988名一般人群。通过访谈、体格检查、超声扫描和改良的Ferriman-Gallwey评分进行横断面研究。850例年龄在20 - 41岁的中国PCOS女性接受了访谈、采血、体格和超声检查。使用Ferriman和Gallwey描述的评分系统对九个部位（嘴唇、下巴、手臂、大腿、胸部、上腹部、下腹部、上背部和下背部）的体毛进行评估；2988名年龄在20 - 45岁的健康女性接受了访谈、体格检查、超声扫描，并由经过培训的妇科医生进行FG评分评估。使用改良FG评分系统评估PCOS中国女性患者和对照组的终末体毛生长情况；九个身体部位的终末毛发生长分布从0至4分进行评分。
我们的研究结果显示，在850例患者中，367例FG评分等于或大于5分[43.2%（367/850）]，282例患者FG评分等于或大于6分[33.18%（282/850）]，21%的患者评分至少为8分。没有人的FG评分等于或大于24分。PCOS患者的多毛症发生率（评分≥5 = 43.2%）显著高于一般人群（评分≥5 = 10%）。嘴唇是850例PCOS患者和一般人群中终末毛发生长最常见的部位（评分0 - 3）。其次是上背部和胸部，只有嘴唇（16例）、大腿（3例）、下腹部（3例）、手臂（1例）、胸部（1例）和下背部（1例）区域记录到4分。没有PCOS患者的下巴、上腹部和上背部评分为超过4分。
我们的数据表明：1）对于未经过筛选的一般人群，改良FG评分5分及以上超出正常范围，在中国女性中几乎构成诊断PCOS可能性的一半；2）嘴唇和上背部是毛发最常见生长的部位（评分1 - 2），但就严重程度而言（评分3 - 4），嘴唇和大腿是毛发最常见生长的部位；3）FG评分对中国人诊断PCOS具有良好的预测价值；4）在中国，PCOS患者的多毛症比一般人群更常见。
