Agarwal S, Kiely P D W
Department of Rheumatology St George's Healthcare NHS Trust Blackshaw Road London SW17 0QT UK.
Rheumatology (Oxford). 2006 Jul;45(7):874-9. doi: 10.1093/rheumatology/kel017. Epub 2006 Jan 31.
To develop objective, isotonic, reliable and valid tests of upper (UL) and lower (LL) limb proximal muscle function for use in the management of idiopathic inflammatory myositis (IIM).
The '1 kg arm lift' test was devised to assess UL function and the '30 s chair stand' test was used for LL function. The tests were performed in 30 control subjects to determine short (24 h) and long (2 week) interval test-retest reliability. Thirty-two patients with IIM were assessed over a period of 2 yr.
In the control group both tests showed excellent test-retest reliability; Spearman correlation >0.8 for both tests over both time intervals. Twenty-four of the 32 IIM patients remained in remission over a mean period of 20.7 months throughout which scores varied by <5 for the '1 kg arm lift' test and <3 for the '30 s chair stand' test from each patient's mean score. Eight patients relapsed with scores falling by >5 for the '1 kg arm lift' test and by >3 for the '30 s chair stand' test from the mean remission score in each case. Both UL and LL scores correlated inversely with serum creatinine kinase.
Two isotonic tests of proximal muscle function are described. They exhibit excellent test-retest reliability and demonstrate construct validity in IIM. Both tests are responsive to changes in disease activity, offer physiological and practical advantages over existing tests of muscle function and are suitable for use in clinical practice.
开发用于特发性炎性肌病（IIM）管理的上肢（UL）和下肢（LL）近端肌肉功能的客观、等张、可靠且有效的测试方法。
设计“1千克手臂上举”测试来评估上肢功能，使用“30秒椅子站立”测试来评估下肢功能。在30名对照受试者中进行这些测试，以确定短期（24小时）和长期（2周）的重测信度。在2年期间对32名IIM患者进行了评估。
在对照组中，两项测试均显示出优异的重测信度；在两个时间间隔内，两项测试的斯皮尔曼相关性均>0.8。32名IIM患者中有24名在平均20.7个月的时间内保持缓解状态，在此期间，“1千克手臂上举”测试的分数变化<5，“30秒椅子站立”测试的分数变化<3（相对于每位患者的平均分数）。8名患者复发，“1千克手臂上举”测试的分数从平均缓解分数下降>5，“30秒椅子站立”测试的分数下降>3。上肢和下肢分数均与血清肌酸激酶呈负相关。
描述了两种近端肌肉功能的等张测试方法。它们具有优异的重测信度，并在IIM中显示出结构效度。两项测试均对疾病活动的变化有反应，与现有的肌肉功能测试相比具有生理和实际优势，适用于临床实践。
