Hirshfeld-Becker Dina R, Biederman Joseph, Henin Aude, Faraone Stephen V, Cayton Gabrielle A, Rosenbaum Jerrold F
Mass. General Hospital Pediatric Psychopharmacology Program, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA.
Am J Psychiatry. 2006 Feb;163(2):265-71. doi: 10.1176/appi.ajp.163.2.265.
This study tested whether behavioral disinhibition is more prevalent among offspring of parents with bipolar disorder than among offspring of parents without bipolar disorder.
The authors conducted a secondary analysis of data from a preexisting high-risk study of offspring at risk for panic disorder and depression (N=278) that had included some children with parents who had bipolar disorder (N=34). Children (ages 2-6) had been classified as behaviorally inhibited, disinhibited, or neither in laboratory assessments.
Offspring of bipolar parents had significantly higher rates of behavioral disinhibition than offspring of parents without bipolar disorder. Behavioral inhibition did not differ between groups. Differences were not accounted for by parental panic disorder or major depression or by parental history of attention deficit hyperactivity disorder, conduct disorder, antisocial personality, or substance use disorders.
Results suggest a familial link between bipolar disorder in parents and behavioral disinhibition in their offspring. Behavioral disinhibition may be a familially transmitted predisposing factor for dysregulatory distress later in life.
本研究旨在检验双相情感障碍患者后代中行为抑制解除是否比无双相情感障碍患者的后代更为普遍。
作者对一项针对惊恐障碍和抑郁症高危后代的现有高危研究（N = 278）的数据进行了二次分析，该研究纳入了一些父母患有双相情感障碍的儿童（N = 34）。在实验室评估中，将2至6岁的儿童分为行为抑制型、行为抑制解除型或两者皆非型。
双相情感障碍父母的后代中行为抑制解除的发生率显著高于无双相情感障碍父母的后代。两组之间的行为抑制没有差异。差异不能由父母的惊恐障碍或重度抑郁症，或父母的注意力缺陷多动障碍、品行障碍、反社会人格或物质使用障碍病史来解释。
结果表明父母的双相情感障碍与后代的行为抑制解除之间存在家族联系。行为抑制解除可能是一种家族遗传的易患因素，会导致日后生活中的调节障碍困扰。
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