Moore Constance M, Biederman Joseph, Wozniak Janet, Mick Eric, Aleardi Megan, Wardrop Megan, Dougherty Meghan, Harpold Terri, Hammerness Paul, Randall Edin, Renshaw Perry F
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA.
Am J Psychiatry. 2006 Feb;163(2):316-8. doi: 10.1176/appi.ajp.163.2.316.
The authors' goal was to investigate phosphatidylinositol and glutamatergic metabolism in the anterior cingulate cortex of children and adolescents with attention deficit hyperactivity disorder (ADHD) alone, children with ADHD plus bipolar disorder, and children with no axis I diagnosis.
Proton spectra were acquired from a 4.8-ml voxel placed in the anterior cingulate cortex of 30 subjects who were 6 to 13 years old. Fifteen subjects had ADHD and no comorbid disorder, eight had ADHD plus bipolar disorder, and seven were healthy comparison subjects.
Children with ADHD had a significantly higher ratio of glutamate plus glutamine to myo-inositol-containing compounds than children with ADHD plus bipolar disorder and healthy children.
myo-Inositol-containing compounds may provide information on the action of antimanic treatments such as lithium, valproate, and carbamazepine. Glutamate and glutamine are measures of glutamatergic neurotransmission and thus may also reflect changes in serotonin and dopamine pathways.
作者的目标是研究单纯患有注意力缺陷多动障碍（ADHD）的儿童和青少年、患有ADHD合并双相情感障碍的儿童以及无轴I诊断的儿童前扣带回皮质中的磷脂酰肌醇和谷氨酸能代谢。
从30名6至13岁受试者前扣带回皮质中一个4.8毫升的体素获取质子谱。15名受试者患有ADHD且无共病，8名患有ADHD合并双相情感障碍，7名是健康对照受试者。
患有ADHD的儿童与患有ADHD合并双相情感障碍的儿童及健康儿童相比，谷氨酸加谷氨酰胺与含肌醇化合物的比率显著更高。
含肌醇化合物可能提供有关锂盐、丙戊酸盐和卡马西平等抗躁狂治疗作用的信息。谷氨酸和谷氨酰胺是谷氨酸能神经传递的指标，因此也可能反映5-羟色胺和多巴胺途径的变化。
