Goldstein Benjamin I, Herrmann Nathan, Shulman Kenneth I
Department of Psychiatry, Sunnybrook and Women's Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.
Am J Psychiatry. 2006 Feb;163(2):319-21. doi: 10.1176/appi.ajp.163.2.319.
This study sought to determine psychiatric comorbidity among elderly individuals with bipolar disorder.
An epidemiological community survey identified 84 elderly (ages >/=65) respondents with bipolar disorder, 1,327 younger adults with bipolar disorder, and 8,121 elderly respondents without bipolar disorder.
Elderly respondents with bipolar disorder reported lifetime and 12-month rates of comorbid alcohol use disorders (38.1%, 38.1%, respectively), dysthymia (15.5%, 7.1%), generalized anxiety disorder (20.5%, 9.5%), and panic disorder (19.0%, 11.9%) that were significantly higher than among elderly respondents without bipolar disorder. They had lower lifetime and 12-month rates of alcohol use disorders and lower 12-month rates of dysthymia and panic disorder than younger adults with bipolar disorder. Elderly men with bipolar disorder reported a greater prevalence of alcoholism; women reported a greater prevalence of panic disorder.
Comorbid axis I disorders, including panic disorder, are common among elderly individuals with bipolar disorder.
本研究旨在确定双相情感障碍老年患者的精神共病情况。
一项流行病学社区调查确定了84名老年（年龄≥65岁）双相情感障碍患者、1327名年轻双相情感障碍患者以及8121名无双相情感障碍的老年受访者。
双相情感障碍老年受访者报告的共病酒精使用障碍的终生患病率和12个月患病率（分别为38.1%和38.1%）、恶劣心境（15.5%和7.1%）、广泛性焦虑症（20.5%和9.5%）以及惊恐障碍（19.0%和11.9%）显著高于无双相情感障碍的老年受访者。他们的酒精使用障碍终生患病率和12个月患病率以及恶劣心境和惊恐障碍的12个月患病率低于年轻双相情感障碍患者。双相情感障碍老年男性报告的酒精中毒患病率更高；女性报告的惊恐障碍患病率更高。
包括惊恐障碍在内的共病I轴障碍在双相情感障碍老年患者中很常见。
