回状硬斑病：系统性硬化症病例中硬斑病皮损的多次复发

Palindromic morphea: multiple recurrence of morphea lesions in a case of systemic sclerosis.

作者信息

Mizutani H, Tanaka H, Okada H, Mizutani T, Shimizu M

机构信息

Department of Dermatology, Mie University School of Medicine, Japan.

出版信息

J Dermatol. 1992 May;19(5):298-301. doi: 10.1111/j.1346-8138.1992.tb03228.x.

DOI:10.1111/j.1346-8138.1992.tb03228.x

PMID:1644954

Abstract

We report an unusual scleroderma case. A 45-year-old woman had recurrent morphea lesions over 10 times in 6 years. She had had preceding inactive systemic scleroderma. New morphea lesions developed cyclically on various portions of her body and improved within 2 years. Interestingly, new lesions have developed on once involved skin as well as uninvolved skin. No exacerbation of systemic scleroderma was induced by outbreaks of new morphea lesions. We could not find a similar case in the literature and named it "Palindromic morphea" because of its unique clinical course. D-penicillamine treatment had a limited effect. Minimal oral prednisolone (5 mg/day) completely suppressed the multiple recurrence of the morphea lesions and enhanced improvement of the sclerosis.

摘要

我们报告一例不寻常的硬皮病病例。一名45岁女性在6年内反复出现局限性硬皮病皮损超过10次。她之前患有静止期系统性硬皮病。新的局限性硬皮病皮损在她身体的不同部位周期性出现，并在2年内好转。有趣的是，新皮损既出现在曾经受累的皮肤部位，也出现在未受累的皮肤部位。新的局限性硬皮病皮损发作并未诱发系统性硬皮病加重。我们在文献中未找到类似病例，并因其独特的临床病程将其命名为“回文性局限性硬皮病”。青霉胺治疗效果有限。小剂量口服泼尼松龙（5毫克/天）完全抑制了局限性硬皮病皮损的多次复发，并促进了硬化改善。