Høstmark Arne T, Tomten Sissel E
Department of Preventive Medicine and Epidemiology, University of Oslo, Norway.
Eur J Cardiovasc Prev Rehabil. 2006 Feb;13(1):87-90. doi: 10.1097/00149831-200602000-00013.
Since information about the association between serum albumin and risk of stroke is limited the purpose of the present paper was to re-investigate this relationship.
The study followed a cross-sectional design.
In the cross-sectional Norwegian Oslo Health Study the concentration of serum albumin and blood pressure was determined in a random sample of 5071 men and women, 30-75 years of age. Logistic regression was used to study the association between the serum albumin concentration and self-reported prevalence of stroke. In the sample there were 122 subjects with a history of stroke and 4949 subjects without.
Low albumin (i.e. < or =47 versus >47 g/l) was associated with increased prevalence of self-reported stroke (odds ratio 1.83; 95% confidence interval, 1.20-2.78; P=0.005), after adjusting for age (< or =45 versus > or =59 years) and sex. Including smoking, blood pressure and length of education into the model did not have any major influence on the result.
Low serum albumin is associated with increased prevalence of self-reported stroke.
由于血清白蛋白与中风风险之间关联的信息有限，本文旨在重新研究这种关系。
本研究采用横断面设计。
在挪威奥斯陆健康横断面研究中，对年龄在30至75岁之间的5071名男性和女性随机样本测定血清白蛋白浓度和血压。采用逻辑回归研究血清白蛋白浓度与自我报告的中风患病率之间的关联。样本中有122名有中风病史的受试者和4949名无中风病史的受试者。
在调整年龄（≤45岁与≥59岁）和性别后，低白蛋白（即≤47与>47 g/L）与自我报告的中风患病率增加相关（比值比1.83；95%置信区间，1.20 - 2.78；P = 0.005）。将吸烟、血压和受教育年限纳入模型对结果没有任何重大影响。
低血清白蛋白与自我报告的中风患病率增加相关。
