Shengli Clinical Medical College of Fujian Medical University, Fuzhou City, China.
Department of Emergency, Fujian Provincial Hospital, Fuzhou City, China.
Medicine (Baltimore). 2023 Sep 8;102(36):e34848. doi: 10.1097/MD.0000000000034848.
This study assessed the relationship between serum albumin levels and adult stroke risk. From the 2009 to 2018 National Health and Nutrition Examination Survey, we performed a cross-sectional study with 17,303 participants who were 40 years of age or higher. A multivariate logistic regression model investigated serum albumin levels and stroke. To investigate apparent nonlinear connections, smoothed curve fitting was used. When a nonlinear relationship was discovered, the inflection point was determined using a recursive method. Serum albumin levels were significantly and inversely linked with the risk of stroke after controlling for possible variables [odds ratio 0.02, 95% confidence interval (0.00, 0.18), P = .0003]. An examination of subgroups revealed that the inverse relationship between serum albumin levels and risk of stroke was statistically significant in men, participants under 60 years old, non-diabetic participants, and hypertensive participants. Serum albumin levels and the risk of stroke were negatively correlated. An increased risk of stroke was linked to lower serum albumin levels.
本研究评估了血清白蛋白水平与成人中风风险之间的关系。我们对 2009 年至 2018 年全国健康和营养调查中的 17303 名年龄在 40 岁及以上的参与者进行了一项横断面研究。使用多变量逻辑回归模型研究了血清白蛋白水平与中风之间的关系。为了研究明显的非线性关系，使用平滑曲线拟合。当发现非线性关系时，使用递归方法确定拐点。在控制了可能的变量后，血清白蛋白水平与中风风险呈显著负相关[比值比 0.02，95%置信区间（0.00，0.18），P =.0003]。亚组分析显示，血清白蛋白水平与中风风险之间的负相关关系在男性、60 岁以下的参与者、非糖尿病参与者和高血压参与者中具有统计学意义。血清白蛋白水平与中风风险呈负相关。较低的血清白蛋白水平与较高的中风风险相关。
