Kennedy L J, Huson H J, Leonard J, Angles J M, Fox L E, Wojciechowski J W, Yuncker C, Happ G M
Center for Integrated Genomic Medical Research, University of Manchester, UK.
Tissue Antigens. 2006 Jan;67(1):53-6. doi: 10.1111/j.1399-0039.2005.00518.x.
Canine hypothyroid disease is similar to Hashimoto's disease in humans, which has been shown to be associated with human major histocompatibility complex (MHC) genes. We have collected 27 Doberman Pinschers affected with primary hypothyroid disease and compared their MHC class II haplotypes with 129 unaffected Doberman Pinschers. Three dog-leucocyte antigen (DLA) genes, DLA-DRB1, DQA1 and DQB1, were characterized by sequence-based typing and assigned to haplotypes for each dog. One rare haplotype was found at an increased frequency in the affected dogs compared to the unaffected dogs (Odds ratio = 2.43, P < 0.02). This haplotype has only been found in Doberman Pinschers and Labradors to date.
犬甲状腺功能减退症与人类的桥本氏病相似，研究表明后者与人类主要组织相容性复合体（MHC）基因有关。我们收集了27只患有原发性甲状腺功能减退症的杜宾犬，并将它们的MHC II类单倍型与129只未受影响的杜宾犬进行了比较。通过基于序列的分型对三个犬白细胞抗原（DLA）基因DLA-DRB1、DQA1和DQB1进行了鉴定，并为每只犬确定了单倍型。与未受影响的犬相比，在受影响的犬中发现一种罕见单倍型的频率有所增加（优势比=2.43，P<0.02）。迄今为止，这种单倍型仅在杜宾犬和拉布拉多犬中被发现。
